Entirely Artificial Signal Transduction with a Primary Messenger

被引：34
作者：
Bernitzki, Kai [1 ]
Schrader, Thomas [1 ]
机构：
[1] Univ Duisburg Essen, Fak Chem, D-45117 Essen, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 43期
关键词：
amphiphiles; FRET; host-guest systems; signal transduction; steroidal lipids; SYNTHETIC ADRENALINE RECEPTORS; CELL-PENETRATING PEPTIDES; AMINO-ALCOHOLS; PHOSPHOLIPIDS; DEHYDROGENASE; RECOGNITION; DERIVATIVES; GRAMICIDIN; BINDING; FRET;
D O I：
10.1002/anie.200902973
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
I saw the sign: An artificial system allows messenger-induced transmembrane signaling. External addition of a primary messenger molecule (DET, see picture) leads to formation of a heterodimeric complex of transmembrane units bearing tryptophan-dansyl (Trp-Dan) donoracceptor pairs, which in turn stimulates a strong FRET on the opposite side of the membrane. © 2009 Wiley-VCH Verlag.
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页码：8001 / 8005
页数：5
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