Prevalence of subclinical amyloidosis in ankylosing spondylitis

被引:0
作者
Singh, Gurmeet [1 ]
Kumari, Niraj [1 ]
Aggarwal, Amita [1 ]
Krishnani, Narendra [1 ]
Misra, Ramnath [1 ]
机构
[1] Sanjay Gandhi Postgrad Inst Med Sci, Dept Immunol, Lucknow 226014, Uttar Pradesh, India
关键词
serum amyloid protein; outcome; spondyloarthropathies;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To study the prevalence of secondary amyloidosis in Indian patients with ankylosing spondylitis (AS). Methods. Seventy-two AS patients with disease duration of more than 5 years were included in this study over a period of one and a half years. Abdominal subcutaneous fat pad aspiration (ASFA) was performed with a fine needle, and smears were examined for apple-green birefringence under polarized light after Congo red staining. The amyloid deposits were graded from 1+ to 3+ by visual inspection. Clinical and laboratory features of the patients were correlated with the absence or presence of amyloid deposits. Results. Five patients (6.9%) with AS were positive for amyloid on ASFA. All the patients had 1+ deposit and were male. None of the patients had clinical amyloidosis. ASFA positive patients had a trend towards older age, longer disease duration, more limitation of the spinal mobility, and significantly lower hemoglobin levels. Conclusion. We found in our population that subclinical amyloid deposits can be detected in 7% of AS patients with disease duration longer than 5 years. There is a need to follow up patients with positive ASFA tests to check for the development of clinical amyloid.
引用
收藏
页码:371 / 373
页数:3
相关论文
共 50 条
  • [11] Guide for the rehabilitation of the spondylitis ankylosing
    Porro Novo, Javier
    Estevez Pereira, Adonis
    Rodriguez Garcia, Annia
    Suarez Martin, Ricardo
    Gonzalez Mendez, Bianka
    [J]. REVISTA CUBANA DE REUMATOLOGIA, 2014, 16 (02): : 245 - 252
  • [12] Measuring enthesitis in ankylosing spondylitis
    Bejia, I
    Ben Hammouda, S
    Said, M
    Ben Salem, K
    Touzi, M
    Bergaoui, N
    [J]. JOINT BONE SPINE, 2006, 73 (02) : 216 - 218
  • [13] Fibromyalgia in patients with ankylosing spondylitis: prevalence and utility of the measures of activity, function and radiological damage
    Almodovar, R.
    Carmona, L.
    Zarco, P.
    Collantes, E.
    Gonzalez, C.
    Mulero, J.
    Sueiro, J. L. F.
    Gratacos, J.
    Torre-Alonso, J. C.
    Juanola, X.
    Batlle, E.
    Ariza, R.
    Font, P.
    [J]. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2010, 28 (06) : S33 - S39
  • [14] Hearing loss in ankylosing spondylitis
    Ajmani, Sajal
    Keshri, Amit
    Srivastava, Rakesh
    Aggarwal, Amita
    Lawrence, Able
    [J]. INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2019, 22 (07) : 1202 - 1208
  • [15] Genetic aspects of ankylosing spondylitis
    Khan, MA
    Ball, EJ
    [J]. BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY, 2002, 16 (04): : 675 - 690
  • [16] Granulomatous ileitis in a patient with ankylosing spondylitis
    Adebayo, Danielle
    Popat, Reena
    Thjodleifsson, Bjarni
    Bjarnason, Ingvar
    [J]. NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY, 2007, 4 (06): : 347 - 351
  • [17] The assessment of ankylosing spondylitis in clinical practice
    Sengupta, Raj
    Stone, Millicent A.
    [J]. NATURE CLINICAL PRACTICE RHEUMATOLOGY, 2007, 3 (09): : 496 - 503
  • [18] Physiotherapy in ankylosing spondylitis: What is the evidence ?
    van der Linden, S
    van Tubergen, A
    Hidding, A
    [J]. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2002, 20 (06) : S60 - S64
  • [19] Imaging study scores for ankylosing spondylitis
    Wendling, Daniel
    Toussirot, Eric
    Streit, Gerald
    Prati, Clement
    [J]. JOINT BONE SPINE, 2006, 73 (06) : 655 - 660
  • [20] SPONDYLOARTHROPATHIES: ANKYLOSING SPONDYLITIS AND PSORIATIC ARTHRITIS
    Albert Antonio, Ramon
    [J]. ATENCION FARMACEUTICA, 2011, 13 (02): : 99 - 112