Depression and chronic pain in the elderly: links and management challenges

被引：296

作者：

Zis, Panagiotis ^{[1
]}

Daskalaki, Argyro ^{[2
]}

Bountouni, Ilia ^{[3
]}

Sykioti, Panagiota ^{[3
]}

Varrassi, Giustino ^{[4
,5
]}

Paladini, Antonella ^{[6
]}

机构：

[1] Sheffield Teaching Hosp NHS Fdn Trust, Acad Dept Neurosci, Sheffield, S Yorkshire, England

[2] Evangelismos Gen Hosp, Dept Neurol, Athens, Greece

[3] South London & Maudsley NHS Fdn Trust, Belgrave Liaison Team, Child & Adolescent Mental Hlth Serv, London, England

[4] Fdn Paolo Procacci, Via Tacito 7, I-00193 Rome, Italy

[5] European League Pain, Rome, Italy

[6] Univ Aquila, Dept MESVA, Laquila, Italy

来源：

CLINICAL INTERVENTIONS IN AGING | 2017年 / 12卷

关键词：

depression; chronic pain; elderly; neuroinflammation; cognitive impairment; pain; COGNITIVE-BEHAVIORAL THERAPY; PARKINSONS-DISEASE PATIENTS; PLACEBO-CONTROLLED TRIAL; NURSING-HOME RESIDENTS; QUALITY-OF-LIFE; LOW-BACK-PAIN; TRICYCLIC ANTIDEPRESSANTS; GENERAL-POPULATION; NEUROPATHIC PAIN; DOUBLE-BLIND;

D O I：

10.2147/CIA.S113576

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Aging is an inevitable process and represents the accumulation of bodily alterations over time. Depression and chronic pain are highly prevalent in elderly populations. It is estimated that 13% of the elderly population will suffer simultaneously from the two conditions. Accumulating evidence suggests than neuroinflammation plays a critical role in the pathogenesis of both depression and chronic pain. Apart from the common pathophysiological mechanisms, however, the two entities have several clinical links. Their management is challenging for the pain physician; however, both pharmacologic and nonpharmacologic approaches are available and can be used when the two conditions are comorbid in the elderly patients.

引用

页码：709 / 720

页数：12

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