A MnO2 nanosheet-assisted GSH detection platform using an iridium(III) complex as a switch-on luminescent probe

被引：114

作者：

Dong, Zhen-Zhen ^{[1
]}

Lu, Lihua ^{[1
,2
]}

Ko, Chung-Nga ^{[1
]}

Yang, Chao ^{[3
]}

Li, Shengnan ^{[3
]}

Lee, Ming-Yuen ^{[3
]}

Leung, Chung-Hang ^{[3
]}

Ma, Dik-Lung ^{[1
]}

机构：

[1] Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China

[2] Qingdao Agr Univ, Coll Chem & Pharmaceut Sci, Qingdao 266109, Peoples R China

[3] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China

来源：

NANOSCALE | 2017年 / 9卷 / 14期

基金：

中国国家自然科学基金;

关键词：

LIQUID-CHROMATOGRAPHY SEPARATION; GLUTATHIONE DETECTION; LIVING CELLS; SELECTIVE DETECTION; GRAPHENE OXIDE; FLUORESCENCE SENSOR; CARBON NANODOTS; SMALL MOLECULES; MESSENGER-RNA; QUANTUM DOTS;

D O I：

10.1039/c6nr08357a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A rapid and sensitive detection platform for GSH has been constructed by combining a MnO2 nanosheet with a luminescent iridium(III) complex [Ir(Cl-phq)2(Cl-phen)]+. The MnO2 nanosheet was prepared by using a facile one-step approach and was characterized by TEM. The luminescence intensity of the detection platform responded linearly with the GSH concentration from 1 to 200 mu M (R-2 = 0.9951), and the detection limit for GSH was 0.13 mu M. More importantly, practical application of the detection platform for visualizing the intracellular GSH distribution in living zebrafish has also been demonstrated.

引用

页码：4677 / 4682

页数：6

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