GLP-1 (7-36) amide: Effects on glucose transport and metabolism in rat adipose tissue

被引：48
|
作者：
Perea, A [1 ]
Vinambres, C [1 ]
Clemente, F [1 ]
VillanuevaPenacarrillo, ML [1 ]
Valverde, I [1 ]
机构：
[1] FDN JIMENEZ DIAZ,DEPT METAB NUTR & HORMONAS,E-28040 MADRID,SPAIN
来源：
HORMONE AND METABOLIC RESEARCH | 1997年 / 29卷 / 09期
关键词：
GLP-1; adipose tissue; glucose metabolism; glucose transport;
D O I：
10.1055/s-2007-979068
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In rat adipocytes, GLP-1 (7-36) amide induced an increment in 2-deoxy-glucose uptake, which was additive to that of insulin. Furthermore, in rat fat, GLP-1 (7-36) amide provoked a rise in glycogen synthesis, glucose oxidation and utilization and lipogenesis, the increments being lower than those obtained with insulin. These data support the idea that GLP-1 exerts insulin-like effects on glucose metabolism in rat adipose tissue, as it does in rat hepatocytes and skeletal muscle, although with a lower potency than that of insulin.
引用
收藏
页码：417 / 421
页数：5
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