A Mild TEMPO-Catalyzed Aerobic Oxidative Conversion of Aldehydes into Nitriles

被引：54

作者：

Fang, Chaojie ^{[1
]}

Li, Meichao ^{[1
]}

Hu, Xinquan ^{[1
,2
]}

Mo, Weimin ^{[1
]}

Hu, Baoxiang ^{[1
]}

Sun, Nan ^{[1
]}

Jin, Liqun ^{[1
]}

Shen, Zhenlu ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China

[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2016年 / 358卷 / 07期

基金：

中国国家自然科学基金;

关键词：

aldehydes; hexamethyldisilazane (HMDS); nitriles; oxidation; oxygen; 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO); TRANSITION-METAL-FREE; AQUEOUS AMMONIA; PRIMARY AMINES; ALCOHOL OXIDATION; OXOAMMONIUM SALT; AROMATIC HALIDES; ARYL BROMIDES; IONIC LIQUID; CYANATION; TRANSFORMATION;

D O I：

10.1002/adsc.201501130

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient method to prepare nitriles from aldehydes using hexamethyldisilazane (HMDS) as the nitrogen source has been developed. The reactions were performed with 2,2,6,6-tetramethylpiperidine l-oxyl (TEMPO) as the catalyst, NaNO2 or TBN as the co-catalyst, and molecular oxygen as the terminal oxidant under mild conditions. A variety of aromatic, heteroaromatic, aliphatic and allylic aldehydes could be converted into their corresponding nitriles in good to excellent yields.

引用

页码：1157 / 1163

页数：7

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