Effects of Probiotics on Malnutrition and Health-Related Quality of Life in Patients Undergoing Peritoneal Dialysis: A Randomized Controlled Trial

被引：23

作者：

Pan, Yangbin ^{[1
,2
]}

Yang, Liyan ^{[2
]}

Dai, Binbin ^{[2
]}

Lin, Beiduo ^{[2
]}

Lin, Songhua ^{[2
]}

Lin, Enqin ^{[2
]}

机构：

[1] Fudan Univ, Shanghai Pudong Hosp, Dept Nephrol, Pudong Med Ctr, 2800 Gongwei Rd, Shanghai 201399, Peoples R China

[2] Fujian Med Univ, Dept Nephrol, Affiliated Hosp 1, Fuzhou, Peoples R China

来源：

JOURNAL OF RENAL NUTRITION | 2021年 / 31卷 / 02期

关键词：

STAGE RENAL-DISEASE; HEMODIALYSIS-PATIENTS; UREMIC TOXINS; LACTOBACILLUS-ACIDOPHILUS; BIFIDOBACTERIUM-LACTIS; P-CRESOL; MANAGEMENT; EPIDEMIOLOGY; MORTALITY;

D O I：

10.1053/j.jrn.2020.04.008

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Objective: Alterations in the gut microbiota and host responses have been implicated in the progression of end-stage renal disease, increased cardiovascular risk, uremic toxicity, and inflammation. The purpose of this study was to evaluate the clinical efficacy of probiotics on malnutrition and health-related quality of life in patients undergoing peritoneal dialysis (PD). Design and Methods: A total of 116 patients undergoing PD were randomly divided into an intervention group (n = 58) and a control group (n = 58). The intervention group received a daily dose of probiotics (1 x 10(9) CFU/day, i.e., 2 capsules, tid) for 2 months, while the control group did not receive probiotics during the same period. Biochemical indicators, physical measurements, and scores on the SF 36 were measured before and 2 months after the intervention. Results: A total of 98 patients completed the study (50 in the intervention group and 48 in the control group). Among patients receiving probiotics, the levels of high-sensitivity C-reactive protein and interleukin-6 decreased after 2 months of treatment, while the serum albumin levels, upper arm circumference, and triceps skinfold thickness increased significantly. The probiotic group had higher scores on the physical functioning and social functioning domains than the control group after 2 months. Conclusions: Probiotics could significantly decrease the serum levels of high-sensitivity C-reactive protein and interleukin-6 and increase the serum albumin levels, upper arm circumference, and triceps skinfold thickness in patients undergoing PD. As a result, malnutrition and health-related quality of life partially improved after probiotic supplementation in patients undergoing PD. (C) 2020 The Authors. Published by Elsevier Inc. on behalf of the National Kidney Foundation, Inc.

引用

页码：199 / 205

页数：7

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