Selective Aerobic Oxidation of Methylarenes to Benzaldehydes Catalyzed by N-Hydroxyphthalimide and Cobalt(II) Acetate in Hexafluoropropan-2-ol

被引：206

作者：

Gaster, Eden ^{[1
]}

Kozuch, Sebastian ^{[1
]}

Pappo, Doron ^{[1
]}

机构：

[1] Ben Gurion Univ Negev, Dept Chem, IL-84105 Beer Sheva, Israel

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 21期

基金：

以色列科学基金会;

关键词：

aerobic oxidation; benzaldehydes; catalysis; C-H activation; solvent effects; MOLECULAR-OXYGEN; FLUORINATED ALCOHOLS; HYDROGEN-PEROXIDE; ACID; FLUOROALCOHOLS; AUTOXIDATION; EPOXIDATION; INHIBITION; CO(OAC)(2); EFFICIENCY;

D O I：

10.1002/anie.201702511

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Efficient and highly selective catalytic conditions for the aerobic autoxidation of methylarenes to benzaldehydes, based on N-hydroxyphthalimide (NHPI) and cobalt(II) acetate in 1,1,1,3,3,3-hexafluoropropan-2-ol (HFIP), were developed. The sustainable conditions enable a multigram scale preparation of benzaldehyde derivatives in high efficiency and with excellent chemoselectivity (up to 99% conversion and 98% selectivity).

引用

页码：5912 / 5915

页数：4

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