Association study of HNF1A in women with polycystic ovary syndrome

被引：4

作者：

Lv, Yue ^{[1
,2
,3
]}

Sun, Changfa ^{[1
,2
,3
]}

Tian, Ye ^{[1
,2
]}

Zhao, Shigang ^{[1
,2
]}

Bian, Yuehong ^{[1
,2
]}

Cheng, Lei ^{[1
,2
]}

Sun, Mei ^{[1
,2
]}

Liu, Hong-Bin ^{[1
,2
,3
]}

Zhao, Han ^{[1
,2
]}

Ma, Jinlong ^{[1
,2
]}

机构：

[1] Shandong Univ, Ctr Reprod Med, 157 Jingliu Rd, Jinan 250021, Peoples R China

[2] Shandong Univ, Key Lab Reprod Endocrinol, Minist Educ, Jinan, Peoples R China

[3] Chinese Univ Hong, Sch Biomed Sci, Chinese Univ Hong Kong Shandong Univ Joint Lab Re, Hong Kong, Hong Kong, Peoples R China

来源：

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 2017年 / 34卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Polycystic ovary syndrome; HNF1A; Genetic association study; Single-nucleotide polymorphisms Yue Lv and Changfa Sun contributed equally to this work; C-REACTIVE PROTEIN; GENOME-WIDE ASSOCIATION; METABOLIC SYNDROME; GENETIC ASSOCIATIONS; SUSCEPTIBILITY LOCI; PREVALENCE; POLYMORPHISMS; DYSLIPIDEMIA; INFLAMMATION; PREDICTORS;

D O I：

10.1007/s10815-017-0905-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

This study aims to ascertain whether an association exists between hepatocyte nuclear factor 1 alpha (HNF1A) and polycystic ovary syndrome (PCOS). One thousand one hundred thirty-eight PCOS and 1125 healthy control Han Chinese women were recruited from Reproductive Hospital Affiliated to Shandong University. Serum hormone, blood lipid level, and genomic DNA were obtained from the peripheral blood for this research. Two single-nucleotide polymorphisms (SNPs)-rs2393791 and rs7305618-located in HNF1A were genotyped using the Sequenom MassARRAY system. The allele frequencies of SNP rs7305618 had significant differences between PCOS patients and controls after adjusting for age and BMI (p = 0.023). Besides, PCOS patients carrying the rs7305618 CC genotype shown a higher testosterone level than the patients with CT + TT genotypes after being adjusted by age and BMI (p = 0.019). A SNP located in the HNF1A gene is associated with PCOS among Han Chinese women. This suggested that variations in HNF1A might confer risk for PCOS.

引用

页码：677 / 682

页数：6

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