Gastric mucosal lesions induced by complete dopamine system failure in rats. The effects of dopamine agents, ranitidine, atropine, omeprazole and pentadecapeptide BPC 157

被引：28

作者：

Sikiric, P ^{[1
]}

Separovic, J ^{[1
]}

Buljat, G ^{[1
]}

Anic, T ^{[1
]}

Stancic-Rokotov, D ^{[1
]}

Mikus, D ^{[1
]}

Duplancic, B ^{[1
]}

Marovic, A ^{[1
]}

Zoricic, I ^{[1
]}

Prkacin, I ^{[1
]}

Lovric-Bencic, M ^{[1
]}

Aralica, G ^{[1
]}

Ziger, T ^{[1
]}

Perovic, D ^{[1
]}

Jelovac, N ^{[1
]}

Dodig, G ^{[1
]}

Rotkvic, I ^{[1
]}

Mise, S ^{[1
]}

Seiwerth, S ^{[1
]}

Turkovic, B ^{[1
]}

Grabarevic, Z ^{[1
]}

Petek, M ^{[1
]}

Rucman, R ^{[1
]}

机构：

[1] Univ Zagreb, Fac Med, Dept Pharmacol, Zagreb 41000, Croatia

来源：

JOURNAL OF PHYSIOLOGY-PARIS | 2000年 / 94卷 / 02期

关键词：

gastric lesions; dopamine; haloperidol; reserpine; haloperidol plus reserpine; dopaminomimetics; ranitidine; omeprazole; atropine; pentadecapeptide BPC 157;

D O I：

10.1016/S0928-4257(00)00147-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Up to now, for gastric lesions potentiation or induction, as well as determination of endogenous dopamine significance, dopamine antagonist or dopamine vesicle depletor were given separately. Therefore, without combination studies, the evidence for dopamine significance remains split on either blockade of dopamine post-synaptic receptor or inhibition of dopamine storage, essentially contrasting with endogenous circumstances, where both functions could be simultaneously disturbed. For this purpose, a co-administration of reserpine and haloperidol, a dopamine granule depletor combined with a dopamine antagonist with pronounced ulcerogenic effect, was tested, and the rats were sacrificed 24 h after injurious agent(s) administration. Haloperidol (5 mg.kg(-1) b.w. i.p.), given alone, produced the lesions in all rats. Reserpine (5 mg.kg(-1) b.w. i.p.), given separately, also produced lesions. When these agents were given together, the lesions were apparently larger than in the groups injured with separate administration of either haloperidol or reserpine alone. Along with our previous results, when beneficial agents were co-administered, all dopaminomimetics (bromocriptine 10 mg, apomophine 1 mg, amphetamine 20 mg.kg(-1) i.p.) apparently attenuated the otherwise consistent haloperidol-gastric lesions. Likewise, an apparent inhibition of the reserpine-lesions was noted as well. However, if they were given in rats injured with combination of haloperidol and reserpine, their otherwise prominent beneficial effects were absent. Ranitidine (10 mg), omeprazole (10 mg), atropine (10 mg), pentadecapeptide BPC 157 (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Ala-Gly-Leu-Val) (10 mu g or 10 ng.kg(-1) i.p.) evidently prevented both haloperidol-gastric lesions and reserpine-gastric lesions. Confronted with potentiated lesions following a combination of haloperidol and reserpine, these agents maintained their beneficial effects, noted in the rats treated with either haloperidol or reserpine alone. The failure of dopaminomimetics could be most likely due to more extensive inhibition of endogenous dopamine system activity, and need for remained endogenous dopamine for their salutary effect, whereas the beneficial activities of ranitidine, omeprazole, atropine, pentadecapeptide BPC 157 following dopamine system inhibition by haloperidol+reserpine suggest their corresponding systems parallel those of dopamine system, and they may function despite extensive inhibition of endogenous dopamine system activity. (C) 2000 Elsevier Science Ltd. Published by Editions scientifiques et medicales Elsevier SAS.

引用

页码：105 / 110

页数：6

共 34 条

[1] Direct cellular effects of some mediators, hormones and growth factor-like agents on denervated (isolated) rat gastric mucosal cells [J].