The yin and yang of imaging tumor associated macrophages with PET and MRI

被引：56

作者：

Mukherjee, Sudip ^{[1
]}

Sonanini, Dominik ^{[2
,3
]}

Maurer, Andreas ^{[2
]}

Daldrup-Link, Heike E. ^{[4
]}

机构：

[1] Rice Univ, Dept Bioengn, Houston, TX 77054 USA

[2] Eberhard Karls Univ Tubingen, Werner Siemens Imaging Ctr, Dept Preclin Imaging & Radiopharm, Univ Hosp Tuebingen, Tubingen, Germany

[3] Eberhard Karls Univ Tubingen, Dept Internal Med 8, Univ Hosp Tuebingen, Tubingen, Germany

[4] Stanford Univ, Dept Radiol, 725 Welch Rd, Stanford, CA 94305 USA

来源：

THERANOSTICS | 2019年 / 9卷 / 25期

关键词：

MRI; PET; Cancer Immunotherapy; Nanoparticles; Radiotracers; Immunotheranostics; Macrophages; IRON-OXIDE NANOPARTICLES; SCAVENGER RECEPTOR CD163; ANTIGEN-PRESENTING CELLS; PROTEIN; 18; KDA; BREAST-CANCER; TRANSLOCATOR PROTEIN; MANNOSE RECEPTOR; M2; MACROPHAGES; INDUCED ARTHRITIS; PROSTATE-CANCER;

D O I：

10.7150/thno.37306

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Tumor associated macrophages (TAM) are key players in the cancer microenvironment. Molecular imaging modalities such as MRI and PET can be used to track and monitor TAM dynamics in tumors non-invasively, based on specific uptake and quantification of MRI-detectable nanoparticles or PET-detectable radiotracers. Particular molecular signatures can be leveraged to target anti-inflammatory TAM, which support tumor growth, and pro-inflammatory TAM, which suppress tumor growth. In addition, TAM-directed imaging probes can be designed to include immune modulating properties, thereby leading to combined diagnostic and therapeutic (theranostic) effects. In this review, we will discuss the complementary role of TAM-directed radiotracers and iron oxide nanoparticles for monitoring cancer immunotherapies with PET and MRI technologies. In addition, we will outline how TAM-directed imaging and therapy is interdependent and can be connected towards improved clinical outcomes

引用

页码：7730 / 7748

页数：19

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