One-Pot Synthesis of 3-Substituted 2-Arylpyrrole in Aqueous Media via Addition-Annulation of Arylboronic Acid and Substituted Aliphatic Nitriles

被引：16

作者：

Yousuf, Md ^{[1
]}

Adhikari, Susanta ^{[1
]}

机构：

[1] Univ Calcutta, Dept Chem, 92 APC Rd, Kolkata 700009, India

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 09期

关键词：

ALKYL ARYL KETONES; PYRROLE SYNTHESIS; ETHYL CYANOACETATE; 3+2 CYCLOADDITION; NATURAL-PRODUCTS; ENERGY-TRANSFER; DERIVATIVES; 3-CYANOPYRROLES; ACTIVATION; ARYLATION;

D O I：

10.1021/acs.orglett.7b00490

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pd(II)-catalyzed C-C coupling reactions between substituted aliphatic nitriles and arylboronic acids followed by in situ cyclodehydration have been employed :for the first time to synthesize a wide variety of 3-substituted 2-aryl-1H-pyrroles in aqueous acetic acid. This one-pot synthesis is green, and it conforms to atom economy. The structures of two representative pyrroles, 3k and 5f, were confirmed by X-ray crystallographic analysis.

引用

页码：2214 / 2217

页数：4

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