Pepsin-Catalyzed Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Derivatives

被引：7
|
作者：
Xie, Zongbo [1 ,2 ]
Zhang, Shiguo [2 ]
Jiang, Guofang [2 ]
Liang, Meng [2 ]
Le, Zhanggao [1 ,2 ]
机构：
[1] East China Univ Technol, Jiangxi Joint Ctr Innovat Mass Spectrometry & Ins, Nanchang 330013, Jiangxi, Peoples R China
[2] East China Univ Technol, Dept Appl Chem, Nanchang 330013, Jiangxi, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 37卷 / 02期
基金：
中国国家自然科学基金;
关键词：
2-aminobenzamide; aldehyde; cyclocondensation; 2,3-dihydroquinazolin-4(1H)-ones; pepsin; REUSABLE HETEROGENEOUS CATALYST; HIGHLY EFFICIENT SYNTHESIS; ACIDIC IONIC LIQUID; PROMISCUITY; WATER;
D O I：
10.6023/cjoc201606030
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The catalytic property of some hydrolases for the cyclocondensation of aldehydes with 2-aminobenzamide was researched in alcohol solvent, and pepsin was selected as the best catalyst. The reaction conditions were optimized through investigating the temperature, the enzyme loading, the ratio of substrates and the reaction time. Under the optimal conditions, 5 mg of pepsin could catalyze the cyclizing reaction of aldehydes with 2-aminobenzamide,and the corresponding 2,3-dihydroquinazolin-4(1H)-ones were successfully obtained in high yields.
引用
收藏
页码：514 / 519
页数：6
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