Mechanisms of immunotherapy resistance: lessons from glioblastoma

被引：529

作者：

Jackson, Christopher M. ^{[1
]}

Choi, John ^{[1
]}

Lim, Michael ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurosurg, Baltimore, MD 21205 USA

来源：

NATURE IMMUNOLOGY | 2019年 / 20卷 / 09期

关键词：

CENTRAL-NERVOUS-SYSTEM; IMMUNE CHECKPOINT BLOCKADE; T-CELL EXHAUSTION; RECURRENT GLIOBLASTOMA; PD-1; BLOCKADE; INTRATUMORAL HETEROGENEITY; NEOANTIGEN LANDSCAPE; CPG OLIGONUCLEOTIDE; MYELOID CELLS; BRAIN;

D O I：

10.1038/s41590-019-0433-y

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Glioblastoma (GBM) is the deadliest form of brain cancer, with a median survival of less than 2 years despite surgical resection, radiation, and chemotherapy. GBM's rapid progression, resistance to therapy, and inexorable recurrence have been attributed to several factors, including its rapid growth rate, its molecular heterogeneity, its propensity to infiltrate vital brain structures, the regenerative capacity of treatment-resistant cancer stem cells, and challenges in achieving high concentrations of chemotherapeutic agents in the central nervous system. Escape from immunosurveillance is increasingly recognized as a landmark event in cancer biology. Translation of this framework to clinical oncology has positioned immunotherapy as a pillar of cancer treatment. Amid the bourgeoning successes of cancer immunotherapy, GBM has emerged as a model of resistance to immunotherapy. Here we review the mechanisms of immunotherapy resistance in GBM and discuss how insights into GBM-immune system interactions might inform the next generation of immunotherapeutics for GBM and other resistant pathologies.

引用

页码：1100 / 1109

页数：10

共 120 条

[1] Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non-Small Cell Lung Cancer [J].

Anagnostou, Valsamo ;

Smith, Kellie N. ;

Forde, Patrick M. ;

Niknafs, Noushin ;

Bhattacharya, Rohit ;

White, James ;

Zhang, Theresa ;

Adleff, Vilmos ;

Phallen, Jillian ;

Wali, Neha ;

Hruban, Carolyn ;

Guthrie, Violeta B. ;

Rodgers, Kristen ;

Naidoo, Jarushka ;

Kang, Hyunseok ;

Sharfman, William ;

Georgiades, Christos ;

Verde, Franco ;

Illei, Peter ;

Li, Qing Kay ;

Gabrielson, Edward ;

Brock, Malcolm V. ;

Zahnow, Cynthia A. ;

Baylin, Stephen B. ;

Scharpf, Robert B. ;

Brahmer, Julie R. ;

Karchin, Rachel ;

Pardoll, Drew M. ;

Velculescu, Victor E. .

CANCER DISCOVERY, 2017, 7 (03) :264-276

[2] Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer [J].

Balachandran, Vinod P. ;

Luksza, Marta ;

Zhao, Julia N. ;

Makarov, Vladimir ;

Moral, John Alec ;

Remark, Romain ;

Herbst, Brian ;

Askan, Gokce ;

Bhanot, Umesh ;

Senbabaoglu, Yasin ;

Wells, Daniel K. ;

Cary, Charles Ian Ormsby ;

Grbovic-Huezo, Olivera ;

Attiyeh, Marc ;

Medina, Benjamin ;

Zhang, Jennifer ;

Loo, Jennifer ;

Saglimbeni, Joseph ;

Abu-Akeel, Mohsen ;

Zappasodi, Roberta ;

Riaz, Nadeem ;

Smoragiewicz, Martin ;

Kelley, Z. Larkin ;

Basturk, Olca ;

Goenen, Mithat ;

Levine, Arnold J. ;

Allen, Peter J. ;

Fearon, Douglas T. ;

Merad, Miriam ;

Gnjatic, Sacha ;

Iacobuzio-Donahue, Christine A. ;

Wolchok, Jedd D. ;

DeMatteo, Ronald P. ;

Chan, Timothy A. ;

Greenbaum, Benjamin D. ;

Merghoub, Taha ;

Leach, Steven D. .

NATURE, 2017, 551 (7681) :512-+

[3] Glioma stem cells promote radioresistance by preferential activation of the DNA damage response [J].

Bao, Shideng ;

Wu, Qiulian ;

McLendon, Roger E. ;

Hao, Yueling ;

Shi, Qing ;

Hjelmeland, Anita B. ;

Dewhirst, Mark W. ;

Bigner, Darell D. ;

Rich, Jeremy N. .

NATURE, 2006, 444 (7120) :756-760

[4] Prevailing over T cell exhaustion: New developments in the immunotherapy of pancreatic cancer [J].

Bauer, Christian ;

Kuehnemuth, Benjamin ;

Duewell, Peter ;

Ormanns, Steffen ;

Gress, Thomas ;

Schnurr, Max .

CANCER LETTERS, 2016, 381 (01) :259-268

[5] "You Shall Not Pass"-tight junctions of the blood brain barrier [J].

Bauer, Hans-Christian ;

Krizbai, Istvan A. ;

Bauer, Hannelore ;

Traweger, Andreas .

FRONTIERS IN NEUROSCIENCE, 2014, 8

[6] Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency [J].

Bouffet, Eric ;

Larouche, Valerie ;

Campbell, Brittany B. ;

Merico, Daniele ;

de Borja, Richard ;

Aronson, Melyssa ;

Durno, Carol ;

Krueger, Joerg ;

Cabric, Vanja ;

Ramaswamy, Vijay ;

Zhukova, Nataliya ;

Mason, Gary ;

Farah, Roula ;

Afzal, Samina ;

Yalon, Michal ;

Rechavi, Gideon ;

Magimairajan, Vanan ;

Walsh, Michael F. ;

Constantini, Shlomi ;

Dvir, Rina ;

Elhasid, Ronit ;

Reddy, Alyssa ;

Osborn, Michael ;

Sullivan, Michael ;

Hansford, Jordan ;

Dodgshun, Andrew ;

Klauber-Demore, Nancy ;

Peterson, Lindsay ;

Patel, Sunil ;

Lindhorst, Scott ;

Atkinson, Jeffrey ;

Cohen, Zane ;

Laframboise, Rachel ;

Dirks, Peter ;

Taylor, Michael ;

Malkin, David ;

Albrecht, Steffen ;

Dudley, Roy W. R. ;

Jabado, Nada ;

Hawkins, Cynthia E. ;

Shlien, Adam ;

Tabori, Uri .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (19) :2206-+

[7] In situ tolerance within the central nervous system as a mechanism for preventing autoimmunity [J].

Brabb, T ;

von Dassow, P ;

Ordonez, N ;

Schnabel, B ;

Duke, B ;

Goverman, J .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (06) :871-880

[8] The Somatic Genomic Landscape of Glioblastoma [J].

Brennan, Cameron W. ;

Verhaak, Roel G. W. ;

McKenna, Aaron ;

Campos, Benito ;

Noushmehr, Houtan ;

Salama, Sofie R. ;

Zheng, Siyuan ;

Chakravarty, Debyani ;

Sanborn, J. Zachary ;

Berman, Samuel H. ;

Beroukhim, Rameen ;

Bernard, Brady ;

Wu, Chang-Jiun ;

Genovese, Giannicola ;

Shmulevich, Ilya ;

Barnholtz-Sloan, Jill ;

Zou, Lihua ;

Vegesna, Rahulsimham ;

Shukla, Sachet A. ;

Ciriello, Giovanni ;

Yung, W. K. ;

Zhang, Wei ;

Sougnez, Carrie ;

Mikkelsen, Tom ;

Aldape, Kenneth ;

Bigner, Darell D. ;

Van Meir, Erwin G. ;

Prados, Michael ;

Sloan, Andrew ;

Black, Keith L. ;

Eschbacher, Jennifer ;

Finocchiaro, Gaetano ;

Friedman, William ;

Andrews, David W. ;

Guha, Abhijit ;

Iacocca, Mary ;

O'Neill, Brian P. ;

Foltz, Greg ;

Myers, Jerome ;

Weisenberger, Daniel J. ;

Penny, Robert ;

Kucherlapati, Raju ;

Perou, Charles M. ;

Hayes, D. Neil ;

Gibbs, Richard ;

Marra, Marco ;

Mills, Gordon B. ;

Lander, Eric ;

Spellman, Paul ;

Wilson, Richard .

CELL, 2013, 155 (02) :462-477

[9] Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs [J].

Brown, Michael C. ;

Holl, Eda K. ;

Boczkowski, David ;

Dobrikova, Elena ;

Mosaheb, Mubeen ;

Chandramohan, Vidya ;

Bigner, Darell D. ;

Gromeier, Matthias ;

Nair, Smita K. .

SCIENCE TRANSLATIONAL MEDICINE, 2017, 9 (408)

[10] Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study [J].

Butowski, Nicholas ;

Colman, Howard ;

De Groot, John F. ;

Omuro, Antonio M. ;

Nayak, Lakshmi ;

Wen, Patrick Y. ;

Cloughesy, Timothy F. ;

Marimuthu, Adhirai ;

Haidar, Sam ;

Perry, Arie ;

Huse, Jason ;

Phillips, Joanna ;

West, Brian L. ;

Nolop, Keith B. ;

Hsu, Henry H. ;

Ligon, Keith L. ;

Molinaro, Annette M. ;

Prados, Michael .

NEURO-ONCOLOGY, 2016, 18 (04) :557-564

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