Diastereoselective synthesis of highly substituted tetrahydropyran-4-ones

被引：41
作者：
Clarke, PA [1 ]
Martin, WHC [1 ]
机构：
[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England
来源：
ORGANIC LETTERS | 2002年 / 4卷 / 25期
关键词：
D O I：
10.1021/ol027081j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] Aldol reactions of beta-ketoesters with aldehydes followed by a tandem Knoevenagel condensation, with a further equivalent of aldehyde, and intramolecular Michael addition produces single diastereomers of highly substituted tetrahydropyran-4-ones.
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页码：4527 / 4529
页数：3
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