CBP/p300 BromodomainMediates Amyloid Formation

被引：2

作者：

Liao, Daiqing ^{[1
]}

机构：

[1] Univ Florida, Coll Med, UF Hlth Canc Ctr, Dept Anat & Cell Biol, Gainesville, FL 32610 USA

来源：

CELL CHEMICAL BIOLOGY | 2017年 / 24卷 / 02期

关键词：

LYSINE ACETYLATION; PROTEIN ACETYLATION; METABOLISM;

D O I：

10.1016/j.chembiol.2017.01.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bromodomains are protein domains that serve as "readers'' of acetylated lysine marks and mediate DNAtemplated processes. In this issue of Cell Chemical Biology, Olzscha et al. (2017) report that the CBP/p300 bromodomains mediate the formation of amyloid-like aggregates and that inhibitors specific to these bromodomains reduce the degree of protein aggregation and mitigate HDAC inhibitor-induced cytotoxicity.

引用

页码：128 / 129

页数：3

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