PEGylated Nanoparticles Obtained through Emulsion Polymerization as Paclitaxel Carriers

被引：29

作者：

Colombo, Claudio ^{[1
]}

Morosi, Lavinia ^{[2
]}

Bello, Ezia ^{[2
]}

Ferrari, Raffaele ^{[2
]}

Licandro, Simonetta Andrea ^{[2
]}

Lupi, Monica ^{[2
]}

Ubezio, Paolo ^{[2
]}

Morbidelli, Massimo ^{[3
]}

Zucchetti, Massimo ^{[2
]}

D'Incalci, Maurizio ^{[2
]}

Moscatelli, Davide ^{[1
]}

Frapolli, Roberta ^{[2
]}

机构：

[1] Politecn Milan, Dept Chem Mat & Chem Engn, I-20131 Milan, Italy

[2] Ist Ric Farmacol Mario Negri, IRCCS, Dept Oncol, I-20156 Milan, Italy

[3] ETH, Inst Chem & Bioengn, CH-8093 Zurich, Switzerland

来源：

MOLECULAR PHARMACEUTICS | 2016年 / 13卷 / 01期

关键词：

Paclitaxel; Cremophor; Breast Cancer; Nanoparticles; Drug Delivery; Emulsion Polymerization; PLGA-BASED NANOPARTICLES; FREE-RADICAL POLYMERIZATION; SPINAL-CORD-INJURY; DRUG-DELIVERY; CLINICAL TRANSLATION; IN-VITRO; FORMULATION; MICROGLIA/MACROPHAGES; NANOMEDICINES;

D O I：

10.1021/acs.molpharmaceut.5b00383

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Polymer nanopartides (NPs) represent a promising way to deliver poorly water-soluble anticancer drugs without the use of unwanted excipients, whose presence can be the cause of severe side effects. In this work, a Cremophor-free formulation for paditaxel (PTX) has been developed by employing PEGylated polymer nanopartides (NPs) as drug delivery carriers based on modified poly(e-caprolactone) macromonomers and synthesized through free radical emulsion polymerization. Paclitaxel was loaded in the NPs in a postsynthesis process which allowed to obtain a drug concentration suitable for in vivo use. In vivo experiments on drug biodistribution and therapeutic efficacy show comparable behavior between the NPs and the Cremophor formulation, also showing good tolerability of the new formulation proposed.

引用

页码：40 / 46

页数：7

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