Antimicrobial properties of hemokinin-1 against strains of Pseudomonas aeruginosa

被引：6
作者：
Berger, Alexandra [1 ,2 ]
Tran, Anne H. [1 ,2 ]
Dedier, Helen [3 ]
Gardam, Michael A. [3 ]
Paige, Christopher J. [1 ,2 ]
机构：
[1] Princess Margaret Hosp, Ontario Canc Inst, Div Stem Cell & Dev Biol, Toronto, ON M5G 2M9, Canada
[2] Univ Toronto, Dept Immunol, Univ Hlth Network, Toronto, ON, Canada
[3] Univ Toronto, Infect Prevent & Control Unit, Univ Hlth Network, Toronto, ON, Canada
来源：
LIFE SCIENCES | 2009年 / 85卷 / 19-20期
关键词：
Hemokinin-1; Substance P; Tachykinin peptide; Pseudomonas aeruginosa; Antimicrobial activity; FIELD GEL-ELECTROPHORESIS; SUBSTANCE-P; EXPRESSION; MICROORGANISMS; LYMPHOPOIESIS; TACHYKININ; RECEPTOR;
D O I：
10.1016/j.lfs.2009.09.011
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aims: In this study, we examined whether hemokinin-1, the newest member of the tachykinin family and a close relative of substance P, has antimicrobial properties which have been attributed to other neuropeptides including substance P. Main methods: Top agar assays were performed to determine the antimicrobial activity of hemokinin-1 and substance P against various microorganisms. Key findings: Here we provide evidence that hemokinin-1 peptide possesses antimicrobial properties against some strains of Pseudomonas aeruginosa, while substance P was only marginally effective. Significance: Our Study is the first to link hemokinin-1 to the essential role of defending the body against microbial challenges and adds hemokinin-1 to the list of potential drugs that Could help in the fight against P. aeruginosa, an opportunistic human pathogen. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：700 / 703
页数：4
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