Antiviral Agents in Development for Zika Virus Infections

被引：59

作者：

Baz, Mariana ^{[1
]}

Boivin, Guy ^{[1
]}

机构：

[1] CHU Quebec, Res Ctr Infect Dis, Quebec City, PQ G1V 4G2, Canada

来源：

PHARMACEUTICALS | 2019年 / 12卷 / 03期

关键词：

Zika virus; antiviral agents; small molecules; virus targets; host targets; repurposing; pre-clinical studies; WEST-NILE-VIRUS; NONSTRUCTURAL PROTEIN NS3; SMALL-MOLECULE INHIBITORS; BROAD-SPECTRUM; DENGUE VIRUS; IN-VITRO; SERINE-PROTEASE; NS2B-NS3; PROTEASE; STRUCTURAL BASIS; APPROVED DRUGS;

D O I：

10.3390/ph12030101

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In 1947, Zika virus (ZIKV), a mosquito-borne flavivirus was identified in Uganda and subsequently spread to Asia and the Pacific regions. In 2015, it was introduced in Brazil causing an important social and sanitary alarm due to its increased virulence and rapid dissemination. Importantly, ZIKV infections have been associated with severe neurological complications such as Guillain-Barre syndrome and microcephaly in fetuses and newborns. Although enormous efforts were made by investigators in the development of effective countermeasures against ZIKV, there is still no approved specific antiviral drug for the treatment of ZIKV infections. Herein, we review several anti ZIKV candidates including drugs targeting both the virus (structural proteins and enzymes) and cellular elements.

引用

页数：15

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