Preparation of a novel chitosan-g-poly(acrylamide)/Zn nanocomposite hydrogel and its applications for controlled drug delivery of ofloxacin

被引：88

作者：

Pathania, Deepak ^{[1
]}

Gupta, Divya ^{[1
]}

Kothiyal, N. C. ^{[2
]}

Sharma, Gaurav ^{[1
]}

Eldesoky, G. E. ^{[3
]}

Naushad, Mu. ^{[3
]}

机构：

[1] Shoolini Univ Biotechnol & Management Sci, Sch Chem, Solan, HP, India

[2] Natl Inst Technol, Dept Chem, Jalandhar 144011, Punjab, India

[3] King Saud Univ, Coll Sci, Dept Chem, Bld 5, Riyadh 11451, Saudi Arabia

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2016年 / 84卷

关键词：

Chitosan; Nanocomposite; Ofloxacin; Acrylamide; Drug delivery; Antibacterial; BIODEGRADABLE POLYMERS; CHITOSAN; RELEASE; PLASTICS; SYSTEMS; NANOPARTICLES; FABRICATION; SEPARATION; REMOVAL; DESIGN;

D O I：

10.1016/j.ijbiomac.2015.12.041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chitosan-g-poly(acrylamide)/Zn (CPA-Zn) nanocomposite was synthesized using simple method in the presence of microwave radiations. CPA-Zn nanocomposite was characterized by various analytical techniques. CPA-Zn nanocomposite was used for controlled drug delivery of ofloxacin. The maximum drug release was 75% which was observed in acidic medium. The cumulative drug release and drug released kinetics of CPA-Zn was investigated. It was noticed that the drug release behavior depended upon the pH of medium as well as on the the nature of matrix. CPA-Zn nanocomposites were also studied for their antibacterial activity against E. coli bacteria. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：340 / 348

页数：9

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