Role of Fine Needle Aspiration Cytology, Cell Block Preparation and CD63, P63 and CD56 Immunostaining in Classifying the Specific Tumor Type of the Lung

被引：10

作者：

Kim, Dong Hoon ^{[1
]}

Kwon, Mi Seon ^{[1
]}

机构：

[1] Dankook Univ, Coll Med, Dept Pathol, Cheonan 330715, Chungnam, South Korea

来源：

ACTA CYTOLOGICA | 2010年 / 54卷 / 01期

关键词：

CD63; CD56; immunohistochemistry; lung cancer; p63; ADHESION MOLECULE; EXPRESSION; CARCINOMAS; TISSUES; TTF-1; IDENTIFICATION; SUPERFAMILY; DIAGNOSIS; CANCERS; NCAM;

D O I：

10.1159/000324967

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Objective To determine whether CD63, p63 and CD56, are useful in the diagnostic evaluation of cytologic samples of pulmonary malignancy. Study Design We explored the utility of using a panel of 13 antibodies, CD63, p63 and CD56, for the diagnosis of lung cancer in cytologic samples consisting of 40 cases of cell block sections and previously Papanicolaou-stained cytologic smear slides. Results The positive rates for CD63, p63 and CD56 were as follows: adenocarcinoma (18/19), (0/19) (0/19) for small cell lung carCinowa (3/8), (0/8), (8/8), and for squamous cell carcinoma (0/13), (12/13), (0/13). All p63 positive cases were squamous cell carcinoma, and all CD56 positive cases were small cell lung carcinoma. CD63 was positive in the majority of adenocarcinomas. Conclusion The panel of CD63, p63 and CD56 appears to be useful in the diagnostic evaluation of cytologic samples of pulmonary malignancy. (Acta Cytol 2010;54:55-59)

引用

页码：55 / 59

页数：5

共 25 条

[21] Expression of p63 in papillary thyroid carcinoma and in Hashimoto's thyroiditis: A pathobiologic link? [J].

Unger, P ;

Ewart, M ;

Wang, BY ;

Gan, L ;

Kohtz, S ;

Burstein, DE .

HUMAN PATHOLOGY, 2003, 34 (08) :764-769

[22] p63 in pulmonary epithelium, pulmonary squamous neoplasms, and other pulmonary tumors [J].

Wang, BY ;

Gil, J ;

Kaufman, D ;

Gan, L ;

Kohtz, DS ;

Burstein, DE .

HUMAN PATHOLOGY, 2002, 33 (09) :921-926

[23] THE INS AND OUTS OF THE TRANSMEMBRANE-4 SUPERFAMILY [J].

WRIGHT, MD ;

TOMLINSON, MG .

IMMUNOLOGY TODAY, 1994, 15 (12) :588-594

[24] Cytology applications of p63 and TTF-1 immunostaining in differential diagnosis of lung cancers [J].

Wu, MX ;

Szporn, AH ;

Zhang, D ;

Wasserman, P ;

Gan, L ;

Miller, L ;

Burstein, DE .

DIAGNOSTIC CYTOPATHOLOGY, 2005, 33 (04) :223-227

[25] p63 and TTF-1 immunostaining - A useful marker panel for distinguishing small cell carcinoma of lung from poorly differentiated squamous cell carcinoma of lung [J].

Wu, MX ;

Wang, B ;

Gil, J ;

Sabo, E ;

Miller, L ;

Gan, L ;

Burstein, DE .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2003, 119 (05) :696-702

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