Routes to building blocks for heterocyclic synthesis by reduction of ketene dithioacetals

被引：21

作者：

Mellor, JM ^{[1
]}

Schofield, SR ^{[1
]}

Korn, SR ^{[1
]}

机构：

[1] N ENGLAND WORKS,ZENECA SPECIAL,HUDDERSFIELD HD2 1FF,W YORKSHIRE,ENGLAND

来源：

TETRAHEDRON | 1997年 / 53卷 / 50期

关键词：

D O I：

10.1016/S0040-4020(97)10136-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two general methods have been developed permitting the effective reduction of ketene dithioacetals to give substituted dithianes. Reduction with magnesium in methanol is less reliable than reduction with zinc in acetic acid. The greater inconsistency of magnesium in methanol has been investigated by a cyclic voltammetric study of the substrates. The utility of the dithianes has been successfully illustrated by cyclisations to afford, after deprotection, a variety of heterocyclic aldehydes. (C) 1997 Elsevier Science Ltd.

引用

页码：17151 / 17162

页数：12

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