Increased C reactive protein, cardiac troponin I and GLS are associated with myocardial inflammation in patients with non-ischemic heart failure

被引：13

作者：

Schwuchow-Thonke, S. ^{[1
,3
]}

Goebel, S. ^{[1
,3
]}

Emrich, T. ^{[4
]}

Schmitt, V. H. ^{[1
]}

Fueting, F. ^{[1
]}

Klank, C. ^{[1
]}

Escher, F. ^{[6
,7
]}

Schultheiss, H. P. ^{[5
]}

Muenzel, T. ^{[1
,3
]}

Keller, K. ^{[1
,2
]}

Wenzel, P. ^{[1
,2
,3
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Ctr Cardiol, Univ Med Ctr Mainz, Cardiol 1, Langenbeckstr 1, D-55131 Mainz, Germany

[2] Johannes Gutenberg Univ Mainz, Ctr Thrombosis & Hemostasis CTH, Univ Med Ctr Mainz, Mainz, Germany

[3] German Ctr Cardiovasc Res DZHK, Partner Site Rhine Main, Mainz, Germany

[4] Johannes Gutenberg Univ Mainz, Univ Med Ctr Mainz, Dept Diagnost & Intervent Radiol, Mainz, Germany

[5] Inst Kardiale Diagnost & Therapie IKDT, Moltkestr 31, D-12203 Berlin, Germany

[6] Charite Univ Med Berlin, Dept Internal Med & Cardiol, Campus Virchow Klinikum, Berlin, Germany

[7] German Ctr Cardiovasc Res DZHK, Partner Site, Berlin, Germany

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

关键词：

VENTRICULAR ENDOMYOCARDIAL BIOPSY; BRAIN NATRIURETIC PEPTIDE; LONGITUDINAL STRAIN; MAGNETIC-RESONANCE; CARDIOMYOPATHY; INFARCTION; BNP; DIAGNOSIS; FEATURES; RECEPTOR;

D O I：

10.1038/s41598-021-82592-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Inflammatory cardiomyopathy diagnosed by endomyocardial biopsy (EMB) is common in non-ischemic heart failure (HF) and might be associated with adverse outcome. We aimed to identify markers predicting myocardial inflammation in HF. We screened 517 patients with symptomatic non-ischemic HF who underwent EMB; 397 patients (median age 54 [IQR 43/64], 28.7% females) were included in this study. 230 patients were diagnosed with myocardial inflammation, defined as >= 7.0 CD3(+) lymphocytes/mm(2) and/or >= 35.0 Mac1 macrophages/mm(2) and were compared to 167 inflammation negative patients. Patients with myocardial inflammation were more often smokers (52.4% vs. 39.8%, p=0.013) and had higher C-reactive protein (CRP) levels (5.4 mg/dl vs. 3.7 mg/dl, p=0.003). In logistic regression models CRP >= 8.15 mg/dl (OR 1.985 [95%CI 1.160-3.397]; p=0.012) and Troponin I (TnI)>= 136.5 pg/ml (OR 3.011 [1.215-7.464]; p=0.017) were independently associated with myocardial inflammation, whereas no association was found for elevated brain natriuretic peptide (OR 1.811 [0.873-3.757]; p=0.111). In prognostic performance calculation the highest positive predictive value (90%) was detected for the combination of Global longitudinal strain (GLS)>= -13.95% and TnI >= 136.5 pg/ml (0.90 (0.74-0.96)). Elevated CRP, TnI and GLS in combination with TnI can be useful to detect myocardial inflammation. Smoking seems to predispose for myocardial inflammation.

引用

页数：11

共 53 条

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