19F NMR as a tool in chemical biology

被引：68

作者：

Gimenez, Diana ^{[1
]}

Phelan, Aoife ^{[2
]}

Murphy, Cormac D. ^{[2
]}

Cobb, Steven L. ^{[1
]}

机构：

[1] Univ Durham, Dept Chem, South Rd, Durham DH1 3LE, England

[2] Univ Coll Dublin, UCD Sch Biomol & Biomed Sci, Dublin 4, Ireland

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 17卷

基金：

英国生物技术与生命科学研究理事会; 爱尔兰科学基金会;

关键词：

biotransformation; chemical biology; fluorine; F-19; NMR; probes; protein structure; NUCLEAR-MAGNETIC-RESONANCE; TERT-BUTYL-HOMOSERINE; RNA G-QUADRUPLEX; ALPHA-SYNUCLEIN; FLUORINE-NMR; AMINO-ACIDS; NONSTRUCTURAL PROTEIN-1; HYDROGEN-PEROXIDE; FUNCTIONAL-STATES; EFFECTOR DOMAIN;

D O I：

10.3762/bjoc.17.28

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We previously reviewed the use of F-19 NMR in the broad field of chemical biology [Cobb, S. L.; Murphy, C. D. J. Fluorine Chem. 2009, 130, 132-140] and present here a summary of the literature from the last decade that has the technique as the central method of analysis. The topics covered include the synthesis of new fluorinated probes and their incorporation into macromolecules, the application of F-19 NMR to monitor protein-protein interactions, protein-ligand interactions, physiologically relevant ions and in the structural analysis of proteins and nucleic acids. The continued relevance of the technique to investigate biosynthesis and biodegradation of fluorinated organic compounds is also described.

引用

收藏

页码：293 / 318

页数：26

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