Prognostic value of CD208-positive cell infiltration in gastric cancer

被引：29

作者：

Ishigami, Sumiya ^{[1
]}

Ueno, Shinichi ^{[1
]}

Matsumoto, Masataka ^{[1
]}

Okumura, Hiroshi ^{[1
]}

Arigami, Takaaki ^{[1
]}

Uchikado, Yasuto ^{[1
]}

Setoyama, Tetsuro ^{[1
]}

Arima, Hideo ^{[1
]}

Sasaki, Ken ^{[1
]}

Kitazono, Masaki ^{[1
]}

Shinchi, Hiroyuki ^{[1
]}

Kijima, Yuko ^{[1
]}

Natsugoe, Shoji ^{[1
]}

机构：

[1] Kagoshima Univ, Sch Med, Kagoshima 8908520, Japan

来源：

CANCER IMMUNOLOGY IMMUNOTHERAPY | 2010年 / 59卷 / 03期

关键词：

Gastric cancer; Dendritic cells; CD208; S100; protein; Survival; DENDRITIC CELLS; MATURATION; EXPRESSION; DENSITY;

D O I：

10.1007/s00262-009-0758-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A new marker, CD208, was recently explored as a mature interdigitating dendritic cell (DC), and the correlation between the infiltration of CD208-positive cells and clinical factors has been reported in various types of cancers. In this study, we tried to clarify the clinical implication of CD208-positive cell infiltration in gastric cancer immunohistochemically. A total of 128 gastric cancer patients who underwent a curative operation were enrolled. DCs in tumor nests were identified with two DC markers, CD208 and S-100 protein (S100), by immunohistochemistry. The correlation between clinicopathological features and the CD208- or S100-positive cell infiltration degree was analyzed. Infiltration of S100-positive cells did not correlate with the degree of CD208-positive cell infiltration. Patients with high CD208-positive cell infiltration in the peritumor had a poorer surgical outcome than those with low CD208 infiltration (p < 0.05). Multivariate analysis revealed that CD208-positive cell infiltration was not an independent prognostic factor. We showed that intratumoral CD208-positive cells, as mature DCs, had an inverse correlation to patients' postoperative outcome in gastric cancer, unlike a conventional DC marker. Evaluation of CD208-positive cell infiltration with S100-positive cell infiltration in gastric cancer is useful to predict antitumor immunological conditions in gastric cancer.

引用

页码：389 / 395

页数：7

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