Perspective: the essential role of NMR in the discovery and characterization of intrinsically disordered proteins

被引：41
|
作者：
Dyson, H. Jane [1 ]
Wright, Peter E. [1 ]
机构：
[1] Scripps Res Inst, Dept Integrat Struct & Computat Biol, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA
来源：
JOURNAL OF BIOMOLECULAR NMR | 2019年 / 73卷 / 12期
基金：
美国国家卫生研究院;
关键词：
Intrinsically disordered proteins; Immunogenic peptides; Protein folding; Relaxation dispersion; 3-DIMENSIONAL SOLUTION STRUCTURE; IMMUNOGENIC PEPTIDE-FRAGMENTS; P53 TRANSACTIVATION DOMAIN; STRUCTURAL BASIS; DYNAMIC CHARACTERIZATION; UNSTRUCTURED PROTEINS; COMPLETE SEQUENCE; DENATURED STATE; CHEMICAL-SHIFTS; WATER SOLUTION;
D O I：
10.1007/s10858-019-00280-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The 2019 ISMAR Prize recognized NMR studies of disordered proteins. Here we provide a highly personal perspective on the discovery of intrinsically disordered proteins and the development and application of NMR methods to characterize their conformational ensembles, dynamics, and interactions.
引用
收藏
页码：651 / 659
页数：9
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