Correlation Between Genetic factors and the Incidence of ocular Hypertension Glaucoma/Normal tension Glaucoma

被引：0

作者：

Feng, Yali ^{[1
]}

Cui, Zhe ^{[1
]}

Xu, Wenshuang ^{[2
]}

机构：

[1] Qiqihar Med Univ, Affiliated Hosp 3, Dept Ophthalmol, Qiqihar, Peoples R China

[2] I Qiqihar Otorhinolaryngol Hosp, Dept Ophthalmol, Qiqihar, Peoples R China

来源：

PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON ELECTRONICS, MECHANICS, CULTURE AND MEDICINE | 2016年 / 45卷

关键词：

Genetic factors; high tension glaucoma; normal tension glaucoma; SNP; polymorphism; OPEN-ANGLE GLAUCOMA; TO-DISC RATIO; ASSOCIATION; VARIANTS; PRESSURE; POAG;

D O I：

暂无

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Objective To explore the correlation between genetic factors and incidence of primary open angle glaucoma ( POAG) Method 1157 cases of patients with POAG composed by 297 NTG and 860 HTG were recruited. Genomic DNA from each case was genotyped for 13 loci of SNPs in 4 genes(TMCO1, CDKN2B-AS1, ATOH7 and SIX1/SIX6. Relationship between SNP allelic frequency and the clinical indexes was calculated. Results The variation of rs4656461 and rs7555523 in TMCO1 were susceptible to the onset of POAG, while the variation of rs1063192, rs523096, rs7049105, rs2157719 in CDKN2B-AS1, rs33912345, rs10483727 in SIX1 / SIX6 related to POAG as protective factors. Variation of rs4656461 and rs7555523 in TMCO1 was susceptible to HTG, while rs523096, rs2157719 in CDKN2B-AS1 and rs33912345, rs10483727 in SIX1 / SIX6 correlated with NTG more protectively, IOP correlated with SNPs of rs523096, rs2157719 in CDKN2B-AS1 and rs33912345, rs10483727 in SIX1 / SIX6 with either multiple correction of age and gender, or Bonferroni adjustment. Conclusion The polymorphism of rs523096, rs2157719 in CDKN2B-AS1 and rs33912345, rs10483727 in SIX1 / SIX6 correlated with NTG significantly, and polymorphism of rs4656461 and rs7555523 in TMCO1 was susceptible to HTG.

引用

页码：695 / 700

页数：6

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