Immunohistochemical expression of heat shock proteins HSP27, HSP70, HSP90 and HSP110 in salivary gland tumors: a study of 50 cases

被引：0
|
作者：
Vanmuylder, N
Evrard, L
Daelemans, P
Van Reck, J
Dourov, N
机构：
[1] Free Univ Brussels, Lab Anat Pathol & Microscopie Elect, B-1070 Brussels, Belgium
[2] Hop Univ Erasme, Serv Stomatol & Chirurg Maxillofaciale, B-1070 Brussels, Belgium
[3] Hop Univ St Pierre, Serv Stomatol & Chirurg Maxillofaciale, B-1000 Brussels, Belgium
来源：
ANNALES DE PATHOLOGIE | 2000年 / 20卷 / 03期
关键词：
immunohistochemistry; heat shock protein; salivary gland tumors;
D O I：
暂无
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Heat shock proteins (HSPs) are known to be increased in response ro biological stress. Recently, some authors described their presence in tumors. Our immunohistochemical investigations revealed the expression of HSP27, HSP70, HSP90 ann HSP110 in most of benign tumors of salvary glands (33 cases). In the malignant tumors. the reaction was immunopositive for HSP70 and HSP90 in 13/17 cases; but HSP27 and HSP110 were only expressed in 5/17 cases. In conclusion HSPs were expressed less in malignant than in benign cells. These results suggest that the loss of some HSPs may be a possible sign of malignancy.
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页码：190 / 195
页数：6
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