Cellular Heterogeneity in Adipose Tissues

被引:83
作者
Corvera, Silvia [1 ]
机构
[1] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA
来源
ANNUAL REVIEW OF PHYSIOLOGY, VOL 83 | 2021年 / 83卷
关键词
adipocyte; adult stem cells; progenitor cells; adipose-derived stem cell; ADSC; obesity; diabetes; adipokine; ADIPOCYTE PROGENITOR CELLS; SINGLE-CELL; STEM-CELLS; FINE-STRUCTURE; IN-VITRO; FAT; WHITE; DIFFERENTIATION; OBESITY; BROWN;
D O I
10.1146/annurev-physiol-031620-095446
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Adipose tissue depots in distinct anatomical locations mediate key aspects of metabolism, including energy storage, nutrient release, and thermogenesis. Although adipocytes make up more than 90% of adipose tissue volume, they represent less than 50% of its cellular content. Here, I review recent advances in genetic lineage tracing and transcriptomics that reveal the identities of the heterogeneous cell populations constituting mouse and human adipose tissues. In addition to mature adipocytes and their progenitors, these include endothelial and various immune cell types that together orchestrate adipose tissue development and functions. One salient finding is the identification of progenitor subtypes that can modulate adipogenic capacity through paracrine mechanisms. Another is the description of fate trajectories of monocyte/macrophages, which can respond maladaptively to nutritional and thermogenic stimuli, leading to metabolic disease. These studies have generated an extraordinary source of publicly available data that can be leveraged to explore commonalities and differences among experimental models, providing new insights into adipose tissues and their role in metabolic disease.
引用
收藏
页码:257 / 278
页数:22
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