Enantioselective Friedel-Crafts Reaction of Indoles with Isatins Catalyzed by Cinchona Alkaloid Silyl Ether Derivative

被引：5

作者：

Zhang, Junwei ^{[1
,2
]}

Wu, Hao ^{[1
,2
]}

Zhang, Weixin ^{[1
]}

Wang, Liming ^{[1
]}

Jin, Ying ^{[1
]}

机构：

[1] Jilin Med Univ, Dept Pharm, Jilin 132013, Jilin, Peoples R China

[2] Yanbian Univ, Dept Pharm, Yanjin 133000, Jilin, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 41卷 / 03期

基金：

中国国家自然科学基金;

关键词：

cinchona alkaloid silyl ether; organocatalysis; isatin; indole; enantioselective Friedel-Crafts reaction; ASYMMETRIC-SYNTHESIS; ALKYLATION; CONSTRUCTION; IMINES; FUNCTIONALIZATION; SPIROOXINDOLES; NITROALKENES; STRATEGIES;

D O I：

10.6023/cjoc202009023

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of cinchona alkaloid silyl ether derivatives have been used to catalyze the enantioselective Friedel-Crafts reaction of indoles with isatins. The resulting 3-hydroxy-2-oxindoles were obtained in good yields (78%similar to 96%) with high enantioselectivities (up to 99% ee). The catalyst type and the substrate scope were broadened in this methodology.

引用

页码：1187 / 1192

页数：6

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