Dysbiosis and Prematurity: Is There a Role for Probiotics?

被引：36

作者：

Baldassarre, Maria Elisabetta ^{[1
]}

Di Mauro, Antonio ^{[1
]}

Capozza, Manuela ^{[1
]}

Rizzo, Valentina ^{[1
]}

Schettini, Federico ^{[1
]}

Panza, Raffaella ^{[1
]}

Laforgia, Nicola ^{[1
]}

机构：

[1] Aldo Moro Univ Bari, Neonatol & Neonatal Intens Care Unit, Dept Biomed Sci & Human Oncol, Pzza Giulio Cesare 11, I-70124 Bari, Italy

来源：

NUTRIENTS | 2019年 / 11卷 / 06期

关键词：

Dysbiosis" [MeSH; Premature Birth" [MeSH; Infant; Premature" [MeSH; Probiotics" [MeSH; NECROTIZING ENTEROCOLITIS; PRETERM INFANTS; DOUBLE-BLIND; FECAL CALPROTECTIN; GUT MICROBIOME; METAANALYSIS; PREVENTION; BIRTH; COLONIZATION; SEPSIS;

D O I：

10.3390/nu11061273

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Healthy microbiota is a critical mediator in maintaining health and it is supposed that dysbiosis could have a role in the pathogenesis of a number of diseases. Evidence supports the hypothesis that maternal dysbiosis could act as a trigger for preterm birth; aberrant colonization of preterm infant gut might have a role in feeding intolerance and pathogenesis of necrotizing enterocolitis. Despite several clinical trials and meta-analyses, it is still not clear if modulation of maternal and neonatal microbiota with probiotic supplementation decreases the risk of preterm birth and its complications.

引用

页数：12

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