Dysbiosis and Prematurity: Is There a Role for Probiotics?

被引：38
作者：
Baldassarre, Maria Elisabetta [1 ]
Di Mauro, Antonio [1 ]
Capozza, Manuela [1 ]
Rizzo, Valentina [1 ]
Schettini, Federico [1 ]
Panza, Raffaella [1 ]
Laforgia, Nicola [1 ]
机构：
[1] Aldo Moro Univ Bari, Neonatol & Neonatal Intens Care Unit, Dept Biomed Sci & Human Oncol, Pzza Giulio Cesare 11, I-70124 Bari, Italy
来源：
NUTRIENTS | 2019年 / 11卷 / 06期
关键词：
Dysbiosis" [MeSH; Premature Birth" [MeSH; Infant; Premature" [MeSH; Probiotics" [MeSH; NECROTIZING ENTEROCOLITIS; PRETERM INFANTS; DOUBLE-BLIND; FECAL CALPROTECTIN; GUT MICROBIOME; METAANALYSIS; PREVENTION; BIRTH; COLONIZATION; SEPSIS;
D O I：
10.3390/nu11061273
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Healthy microbiota is a critical mediator in maintaining health and it is supposed that dysbiosis could have a role in the pathogenesis of a number of diseases. Evidence supports the hypothesis that maternal dysbiosis could act as a trigger for preterm birth; aberrant colonization of preterm infant gut might have a role in feeding intolerance and pathogenesis of necrotizing enterocolitis. Despite several clinical trials and meta-analyses, it is still not clear if modulation of maternal and neonatal microbiota with probiotic supplementation decreases the risk of preterm birth and its complications.
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页数：12
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