Unusual Manifestation of Extraosseous Ewing Sarcoma: Report of 3 Cases

被引：1

作者：

Ioannidou, M. ^{[1
,7
]}

Tsotridou, E. ^{[1
]}

Samoladas, E. ^{[2
]}

Tragiannidis, A. ^{[1
]}

Kouskouras, K. ^{[3
]}

Sfougaris, D. ^{[4
]}

Spyridakis, I. ^{[5
]}

Foroulis, C. ^{[6
]}

Galli-Tsinopoulou, A. ^{[1
]}

Hatzipantelis, E. ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, AHEPA Univ Gen Hosp, Dept Pediat 2, Childrens & Adolescents Hematol Oncol Unit, Thessaloniki, Greece

[2] Aristotle Univ Thessaloniki, Gennimatas Gen Hosp, Dept Orthoped Surg 2, Thessaloniki, Greece

[3] Aristotle Univ Thessaloniki, AHEPA Univ Gen Hosp, Dept Radiol, Thessaloniki, Greece

[4] Aristotle Univ Thessaloniki, Gennimatas Gen Hosp, Dept Pediat Surg 1, Thessaloniki, Greece

[5] Aristotle Univ Thessaloniki, Papageorgiou Gen Hosp, Dept Pediat Surg 2, Thessaloniki, Greece

[6] Aristotle Univ Thessaloniki, AHEPA Univ Gen Hosp, Dept Cardiothorac Surg, Thessaloniki, Greece

[7] AHEPA Univ Gen Hosp, Dept Pediat 2, Childrens & Adolescents Hematol Oncol Unit, AUTh, St Kiriakidi 1, Thessaloniki 54621, Greece

来源：

BALKAN JOURNAL OF MEDICAL GENETICS | 2022年 / 25卷 / 02期

关键词：

cytogenetics; extraosseous Ewing sarcoma; surgical resection; PRIMITIVE NEUROECTODERMAL TUMOR; FAMILY; EXTRASKELETAL; BONE; TRANSLOCATION; OPPORTUNITIES;

D O I：

10.2478/bjmg-2022-0022

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Ewing sarcoma (ES), described as a diffuse endothelioma of the bone, is divided into two categories: osseous and extraosseous, which mainly affects adolescents. Extraosseous Ewing Sarcomas (EES) are rare tumors originating from soft tissues. Their clinical presentation depends mainly on the primary location of the tumor and are highly chemosensitive and radiosensitive. The purpose of this study was to describe the clinical characteristics and outcomes of 3 children with EES and uncommon presentation treated in our Unit. The diagnosis of EES was confirmed by biopsy and cytogenetic analysis with fluorescence in situ hybridization (FISH). Surgical excision was planned as primary treatment, followed by adjuvant chemotherapy according to EURO-E.W.I.N.G protocol. To date, all patients are alive, 1, 3 and 4 years after completion of treatment, with no signs of recurrence or metastasis.

引用

页码：77 / 81

页数：5

共 36 条

[1] Extraskeletal Ewing sarcoma: Diagnosis, management and prognosis [J].

Abboud, Abdallah ;

Masrouha, Karim ;

Saliba, Maelle ;

Haidar, Rachid ;

Saab, Raya ;

Khoury, Nabil ;

Tawil, Ayman ;

Saghieh, Said .

ONCOLOGY LETTERS, 2021, 21 (05)

[2]

Ahmad R, 1999, CANCER, V85, P725, DOI 10.1002/(SICI)1097-0142(19990201)85:3<725::AID-CNCR23>3.3.CO

[3]

2-U

[4] Clinical Features and Outcomes in Patients with Extraskeletal Ewing Sarcoma [J].

Applebaum, Mark A. ;

Worch, Jennifer ;

Matthay, Katherine K. ;

Goldsby, Robert ;

Neuhaus, John ;

West, Daniel C. ;

DuBois, Steven G. .

CANCER, 2011, 117 (13) :3027-3032

[5] Adjuvant and neoadjuvant chemotherapy for Ewing sarcoma family tumors in patients aged between 40 and 60 - Report of 35 cases and comparison of results with 586 younger patients treated with the same protocols in the same years [J].

Bacci, Gaetano ;

Balladelli, Alba ;

Forni, Cristiana ;

Ferrari, Stefano ;

Longhi, Alessandra ;

Bacchini, Patrizia ;

Alberghini, Marco ;

Fabbri, Nicola ;

Benassi, MariaSerena ;

Briccoli, Antonio ;

Picci, Piero .

CANCER, 2007, 109 (04) :780-786

[6] Ewing's sarcoma [J].

Balamuth, Naomi J. ;

Womer, Richard B. .

LANCET ONCOLOGY, 2010, 11 (02) :184-192

[7] Updates in the Treatment of Bone Cancer [J].

Biermann, J. Sybil .

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2013, 11 (5.5) :681-683

[8] Pediatric Extraskeletal Ewing Sarcoma Originating in the Heart: A Case Report and Review of the Literature [J].

Buffoni, Isabella ;

Nuri, Halkawt ;

Pome', Giuseppe ;

Sementa, Angela R. ;

Stagnaro, Nicola ;

Barra, Salvina ;

Manzitti, Carla ;

Garaventa, Alberto .

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2021, 43 (04) :147-151

[9] Bone sarcomas: ESMO-PaedCan-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up [J].

Casali, P. G. ;

Bielack, S. ;

Abecassis, N. ;

Aro, H. T. ;

Bauer, S. ;

Biagini, R. ;

Bonvalot, S. ;

Boukovinas, I. ;

Bovee, J. V. M. G. ;

Brennan, B. ;

Brodowicz, T. ;

Martin-Broto, J. ;

Brugieres, L. ;

Buonadonna, A. ;

De Alava, E. ;

Dei Tos, A. P. ;

Del Muro, X. G. ;

Dileo, P. ;

Dhooge, C. ;

Eriksson, M. ;

Fagioli, F. ;

Fedenko, A. ;

Ferraresi, V. ;

Ferrari, A. ;

Ferrari, S. ;

Frezza, A. M. ;

Gaspar, N. ;

Gasperoni, S. ;

Gelderblom, H. ;

Gil, T. ;

Grignani, G. ;

Gronchi, A. ;

Haas, R. L. ;

Hassan, B. ;

Hecker-Nolting, S. ;

Hohenberger, P. ;

Issels, R. ;

Joensuu, H. ;

Jones, R. L. ;

Judson, I. ;

Jutte, P. ;

Kaal, S. ;

Kager, L. ;

Kasper, B. ;

Kopeckova, K. ;

Krakorova, D. A. ;

Ladenstein, R. ;

Le Cesne, A. ;

Lugowska, I. ;

Merimsky, O. .

ANNALS OF ONCOLOGY, 2018, 29 :79-95

[10] Comparison of clinical features and outcomes in patients with extraskeletal versus skeletal localized Ewing sarcoma: A report from the Children's Oncology Group [J].

Cash, Thomas ;

McIlvaine, Elizabeth ;

Krailo, Mark D. ;

Lessnick, Stephen L. ;

Lawlor, Elizabeth R. ;

Laack, Nadia ;

Sorger, Joel ;

Marina, Neyssa ;

Grier, Holcombe E. ;

Granowetter, Linda ;

Womer, Richard B. ;

DuBois, Steven G. .

PEDIATRIC BLOOD & CANCER, 2016, 63 (10) :1771-1779

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