Consecutive multicomponent reactions for the synthesis of complex molecules (vol 17, pg 7632, 2019)

被引：3

作者：

Zhi, Sanjun ^{[1
]}

Ma, Xiaoming ^{[2
]}

Zhang, Wei ^{[3
]}

机构：

[1] Huaiyin Normal Univ, Jiangsu Key Lab Chem Low Dimens Mat, Huaian 223300, Jiangsu, Peoples R China

[2] Changzhou Univ, Sch Pharmaceut Engn & Life Sci, Changzhou 213164, Jiangsu, Peoples R China

[3] Univ Massachusetts, 100 Morrissey Blvd, Boston, MA 02125 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 33期

关键词：

Molecular complexity - Molecular scaffolds - Multi-component reactions - Multicomponent reactions (MCRs) - Organic and biomolecular chemistries - Structural diversity - Synthetic efficiency - Synthetic methods;

D O I：

10.1039/c9ob90135c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Multicomponent reactions (MCRs) involving a minimum of three reactants or reaction centers are conducted in one pot and with a single operational step. This synthetic method has a good pot, atom and step economy in the preparation of diverse and complex molecular scaffolds. Consecutive MCRs, also known as sequential or multiple MCRs, by combining two or more MCRs, exhibit even higher synthetic efficiency, product structural diversity, and molecular complexity. This review article highlights the Ugi, Groebke-Blackburn-Bienaymé, Biginelli, Huisgen, Petasis, Gewald, and Asinger reaction-initiated consecutive MCRs. © The Royal Society of Chemistry 2019.

引用

页码：7794 / 7794

页数：1