New Targets in the Drug Treatment of Heart Failure

被引：2

作者：

Iwaz, James A. ^{[1
,2
]}

Lee, Elizabeth ^{[2
]}

Aramin, Hermineh ^{[2
]}

Romero, Danilo ^{[2
]}

Iqbal, Navaid ^{[2
]}

Kawahara, Matt ^{[2
]}

Khusro, Fatima ^{[2
]}

Knight, Brian ^{[2
]}

Patel, Minal V. ^{[2
]}

Sharma, Sumita ^{[2
]}

Maisel, Alan S. ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, San Diego Med Ctr, San Diego, CA 92103 USA

[2] VA San Diego Healthcare Syst, Vet Affairs Med Ctr, San Diego, CA 92161 USA

来源：

DRUGS | 2016年 / 76卷 / 02期

关键词：

CORONARY-ARTERY-DISEASE; VENTRICULAR SYSTOLIC DYSFUNCTION; RECOMBINANT HUMAN NEUREGULIN-1; CONVERTING ENZYME-INHIBITION; CARDIAC RYANODINE RECEPTORS; EXPERT CONSENSUS DOCUMENT; BRAIN NATRIURETIC PEPTIDE; PROGNOSTIC VALUE; SOLUBLE ST2; TASK-FORCE;

D O I：

10.1007/s40265-015-0498-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Heart failure is a complex syndrome that has been a major contributor to readmissions into hospitals in the USA. Currently, a large number of medications are being used to treat the symptoms of the disease-digoxin, diuretics, renin-angiotensin-aldosterone system inhibitors, beta-blockers, and vasodilators. There is no doubt that the given pharmaceutical therapy has been effective in lowering hospital readmission rates and prolonging life in individual chronic heart failure patients. Despite this, admission rates following heart failure hospitalization remain high, resulting in a substantial financial strain on healthcare institutions. Clearly, there is much room for improvement in heart failure therapy and management in reducing readmission rates. In this review, we address the unmet needs in the current drug treatment of chronic heart failure and describe novel drug targets that are currently under investigation.

引用

页码：187 / 201

页数：15

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