Serotonin regulates hippocampal glucocorticoid receptor expression via a 5-HT7 receptor

被引：97
作者：
Laplante, P
Diorio, J
Meaney, MJ
机构：
[1] McGill Univ, Dept Psychiat, Dev Neuroendocrinol Lab, Douglas Hosp,Res Ctr, Verdun, PQ H4H 1R3, Canada
[2] McGill Univ, Dept Neurol & Neurosurg, Dev Neuroendocrinol Lab, Douglas Hosp,Res Ctr, Verdun, PQ H4H 1R3, Canada
来源：
DEVELOPMENTAL BRAIN RESEARCH | 2002年 / 139卷 / 02期
基金：
加拿大健康研究院;
关键词：
glucocorticoid receptor; serotonin; serotonin-7; receptor; cAMP; hippocampus;
D O I：
10.1016/S0165-3806(02)00550-3
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Glucocorticoid receptor expression in primary hippocampal cell cultures was significantly increased with either 10 mM 8-bromo cAMP, 50 nM 5-carboxamidotryptamine (5-CT), a potent 5-HT7 receptor agonist, or 100 nM 5-HT. The effect of 5-HT or 5-CT was blocked with methiothepin or by a protein kinase A inhibitor, but not pindolol. These results suggest that the effects of 5-HT on hippocampal GR expression is mediated by a 5-HT7 receptor. (C) 2002 Elsevier Science B.V. All rights reserved.
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页码：199 / 203
页数：5
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