Cobalt-Catalyzed Alkylation of Aromatic Amines by Alcohols

被引：315

作者：

Roesler, Sina ^{[1
]}

Ertl, Michael ^{[1
]}

Irrgang, Torsten ^{[1
]}

Kempe, Rhett ^{[1
]}

机构：

[1] Univ Bayreuth, Anorgan Chem Katalysatordesign 2, D-95440 Bayreuth, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 50期

关键词：

alcohols; amine alkylation; base metals; hydrogen-transfer catalysis; cobalt; MILD REACTION CONDITIONS; PNP PINCER COMPLEXES; ALKENE HYDROGENATION; SELECTIVE HYDROGENATION; OLEFIN HYDROGENATION; IRIDIUM CATALYSTS; N-ALKYLATION; C=N BONDS; DEHYDROGENATION; DIAMINES;

D O I：

10.1002/anie.201507955

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The implementation of inexpensive, Earth-abundant metals in typical noble-metal-mediated chemistry is a major goal in homogeneous catalysis. A sustainable or green reaction that has received a lot of attention in recent years and is preferentially catalyzed by Ir or Ru complexes is the alkylation of amines by alcohols. It is based on the borrowing hydrogen or hydrogen autotransfer concept. Herein, we report on the Co-catalyzed alkylation of aromatic amines by alcohols. The reaction proceeds under mild conditions, and selectively generates monoalkylated amines. The observed selectivity allows the synthesis of unsymmetrically substituted diamines. A novel Co complex stabilized by a PN5P ligand catalyzes the reactions most efficiently.

引用

页码：15046 / 15050

页数：6

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