Methylmercury poisoning in common marmosets - MRI findings and peripheral nerve lesions

被引：14

作者：

Eto, K

Yasutake, A

Korogi, Y

Akima, M

Shimozeki, T

Tokunaga, H

Kuwana, T

Kaneko, Y

机构：

[1] Minist Environm, Natl Inst Minamata Dis, Minamata, Kumamoto 8670008, Japan

[2] Kumamoto Univ, Sch Med, Dept Radiol, Kumamoto 860, Japan

[3] Toho Univ, Sch Med, Dept Pathol, Tokyo, Japan

[4] Kumamoto Univ, Sch Med, Dept Surg Pathol, Kumamoto 860, Japan

[5] Anim Care Co Ltd, Lab Anim Technol, Tokyo, Japan

来源：

TOXICOLOGIC PATHOLOGY | 2002年 / 30卷 / 06期

关键词：

methylmercury; common marmoset; MRI (magnetic resonance imaging); peripheral neuropathy; axonal degeneration;

D O I：

10.1080/01926230290166814

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Common marmosets were used as model animals for methylmercury (MeHg) poisoning. Six marmosets were given MeHg of 5 ppm Hg in drinking water. The animals were divided into 3 groups of 2 each. The first group was examined for acute symptomatic MeHg poisoning. They were given MeHg for 70 and 90 days, respectively, to manifest severe symptoms. The second group was sacrificed after 38 days of MeHg exposure, when they had acute-subclinical MeHg poisoning. The third group of animals was exposed for 21 days, and then observed for 2.5 years without MeHg exposure. One of them showed typical symptoms of MeHg poisoning after MeHg exposure had ended, but the other one showed only slight symptoms without ataxia. This experiment demonstrated that MeHg causes pathological changes in neural tissues including the peripheral nerves in common marmosets. Furthermore, common marmosets were found to show MeHg-induced pathological changes similar to those in humans in the cerebrum and cerebellum.

引用

页码：723 / 734

页数：12

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