The role of neoadjuvant therapy in pancreatic cancer: a review

被引：31

作者：

Russo, Suzanne ^{[1
]}

Ammori, John ^{[2
]}

Eads, Jennifer ^{[3
]}

Dorth, Jennifer ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Radiat Oncol, Univ Hosp Seidman Canc Ctr, Case Comprehens Canc Ctr, 10900 Euclid Ave, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Dept Surg, Univ Hosp Seidman Canc Ctr, Case Comprehens Canc Ctr, 10900 Euclid Ave, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Dept Med, Univ Hosp Seidman Canc Ctr, Case Comprehens Canc Ctr, 10900 Euclid Ave, Cleveland, OH 44106 USA

来源：

FUTURE ONCOLOGY | 2016年 / 12卷 / 05期

关键词：

5-fluorouracil; abraxane; capecitabine; chemotherapy; docetaxel; gemcitabine; irinotecan; oxaliplatin; pancreatic cancer; radiation; surgery; PHASE-II TRIAL; FULL-DOSE GEMCITABINE; LOCALLY ADVANCED ADENOCARCINOMA; RANDOMIZED CONTROLLED-TRIAL; SHORT-COURSE CHEMORADIATION; COOPERATIVE-ONCOLOGY-GROUP; BODY RADIATION-THERAPY; TUMOR-VEIN INTERFACE; PROTON-BEAM THERAPY; PREOPERATIVE CHEMORADIATION;

D O I：

10.2217/fon.15.335

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Controversy remains regarding neoadjuvant approaches in the treatment of pancreatic cancer. Neoadjuvant therapy has several potential advantages over adjuvant therapy including earlier delivery of systemic treatment, in vivo assessment of response, increased resectability rate in borderline resectable patients and increased margin-negative resection rate. At present, there are no randomized data favoring neoadjuvant over adjuvant therapy and multiple neoadjuvant approaches are under investigation. Combination chemotherapy regimens including 5-fluorouracil, irinotecan and oxaliplatin, gemcitabine with or without abraxane, or docetaxel and capecitabine have been used in the neoadjuvant setting. Radiation and chemoradiation have also been incorporated into neoadjuvant strategies, and delivery of alternative fractionation regimens is being explored. This review provides an overview of neoadjuvant therapies for pancreatic cancer.

引用

页码：669 / 685

页数：17

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