Construction of recombinant fowlpox virus(rFpv) expressing HIV-1 Gag-pol protein

被引：2

作者：

Teng Hong-gang ^{[1
]}

Lu Shuai-ran ^{[1
]}

Liu Da-wei ^{[1
]}

Jiang Chun-lai ^{[1
]}

Zhang Xi-zhen ^{[1
]}

Yu Xiang-hui ^{[1
]}

Kong Wei ^{[1
]}

机构：

[1] Jilin Univ, Coll Life Sci, Vaccine Res Ctr, Changchun 130012, Peoples R China

来源：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2007年 / 23卷 / 01期

基金：

中国国家自然科学基金;

关键词：

HIV; Gag-pol; recombinant fowlpox virus; rFPV;

D O I：

10.1016/S1005-9040(07)60013-0

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The induction of human immunodeficiency virus(HIV)-specific T-cell response is generally considered as critical to the development of effective immunity to HIV type 1 (HIV-1). Recombinant Avipoxvirus vectors are used widely for vaccination against HIV-1, where the induction of a cytotoxic CD8+ T-cell(CTL) response seems to be an important component of protective immunity. A recombinant fowlpox virus(rFPV/Gag-pol) expressing the Gag-pol protein of HIV was constructed and characterized. The specific expression protein in CEF cells infected by recombinant fowlpox and the specific antibody in the sera of mice immunized with rFPV were analyzed via Western-blot.

引用

页码：64 / 68

页数：5

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