KLF Family Members Regulate Intrinsic Axon Regeneration Ability

被引：560

作者：

Moore, Darcie L. ^{[1
,2
]}

Blackmore, Murray G. ^{[3
]}

Hu, Ying ^{[1
]}

Kaestner, Klaus H. ^{[4
]}

Bixby, John L. ^{[2
,3
]}

Lemmon, Vance P. ^{[2
,3
]}

Goldberg, Jeffrey L. ^{[1
,2
]}

机构：

[1] Univ Miami, Miller Sch Med, Bascom Palmer Eye Inst, Miami, FL 33136 USA

[2] Univ Miami, Miller Sch Med, Neurosci Program, Miami, FL 33136 USA

[3] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Miami, FL 33136 USA

[4] Univ Penn, Dept Genet, Philadelphia, PA 19104 USA

来源：

SCIENCE | 2009年 / 326卷 / 5950期

关键词：

KRUPPEL-LIKE FACTOR; CENTRAL-NERVOUS-SYSTEM; IN-VIVO; TRANSCRIPTION FACTORS; DEVELOPMENTAL LOSS; SPINAL-CORD; CELLS; PATHWAY; GROWTH; GENE;

D O I：

10.1126/science.1175737

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neurons in the central nervous system (CNS) lose their ability to regenerate early in development, but the underlying mechanisms are unknown. By screening genes developmentally regulated in retinal ganglion cells (RGCs), we identified Kruppel-like factor-4 (KLF4) as a transcriptional repressor of axon growth in RGCs and other CNS neurons. RGCs lacking KLF4 showed increased axon growth both in vitro and after optic nerve injury in vivo. Related KLF family members suppressed or enhanced axon growth to differing extents, and several growth-suppressive KLFs were up-regulated postnatally, whereas growth-enhancing KLFs were down-regulated. Thus, coordinated activities of different KLFs regulate the regenerative capacity of CNS neurons.

引用

页码：298 / 301

页数：4

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