Bioinspired design of nanocages by self-assembling triskelion peptide elements

被引：139
作者：
Ghosh, Surajit
Reches, Meital
Gazit, Ehud [1 ]
Verma, Sandeep
机构：
[1] Tel Aviv Univ, George S Wise Fac Life Sci, Dept Mol Microbiol & Biotechnol, IL-69978 Tel Aviv, Israel
[2] Indian Inst Technol, Dept Chem, Kanpur 208016, Uttar Pradesh, India
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 12期
关键词：
electron microscopy; fluorescence; peptides; self-assembly; vesicles;
D O I：
10.1002/anie.200604383
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Winning the three-legged race: Rapid self-organization of a tripodal aromatic dipeptide conjugate on a tris(2-amino-ethyl)amine scaffold leads to a vesicular morphology (upper image). The structures can trap a fluorescent dye (lower image) and release it upon acidification, suggesting the use of such stimuli-responsive materials as potential delivery vehicles. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：2002 / 2004
页数：3
相关论文
共 31 条
[1]   Formation of stable vesicles from N- or 3-alkylindoles:: Possible evidence for tryptophan as a membrane anchor in proteins [J].
Abel, E ;
De Wall, SL ;
Edwards, WB ;
Lalitha, S ;
Covey, DF ;
Gokel, GW .
JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (19) :5901-5909
[2]   Responsive gels formed by the spontaneous self-assembly of peptides into polymeric beta-sheet tapes [J].
Aggeli, A ;
Bell, M ;
Boden, N ;
Keen, JN ;
Knowles, PF ;
McLeish, TCB ;
Pitkeathly, M ;
Radford, SE .
NATURE, 1997, 386 (6622) :259-262
[3]   Bioinspired polymeric materials: in-between proteins and plastics [J].
Barron, AE ;
Zuckermann, RN .
CURRENT OPINION IN CHEMICAL BIOLOGY, 1999, 3 (06) :681-687
[4]   AROMATIC-AROMATIC INTERACTION - A MECHANISM OF PROTEIN-STRUCTURE STABILIZATION [J].
BURLEY, SK ;
PETSKO, GA .
SCIENCE, 1985, 229 (4708) :23-28
[5]   Fabrication of coaxial metal nanocables using a self-assembled peptide nanotube scaffold [J].
Carny, Ohad ;
Shalev, Deborah E. ;
Gazit, Ehud .
NANO LETTERS, 2006, 6 (08) :1594-1597
[6]  
Dujardin E, 2002, ADV MATER, V14, P775, DOI 10.1002/1521-4095(20020605)14:11<775::AID-ADMA775>3.0.CO
[7]  
2-0
[8]   Peptides as novel smart materials [J].
Fairman, R ;
Åkerfeldt, KS .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2005, 15 (04) :453-463
[9]   Conformation of a clathrin triskelion in solution [J].
Ferguson, Matthew L. ;
Prasad, Kondury ;
Sackett, Dan L. ;
Boukari, Hacene ;
Lafer, Eileen M. ;
Nossa, Ralph .
BIOCHEMISTRY, 2006, 45 (18) :5916-5922
[10]   Molecular model for a complete clathrin lattice from electron cryomicroscopy [J].
Fotin, A ;
Cheng, YF ;
Sliz, P ;
Grigorieff, N ;
Harrison, SC ;
Kirchhausen, T ;
Walz, T .
NATURE, 2004, 432 (7017) :573-579
1234