RETRACTED: Influence of miR-376c-3p/SYF2 Axis on the Progression of Gastric Cancer (Retracted Article)

被引：0
作者：
Liu, Bin [1 ]
Li, Guangchun [1 ]
Zhang, Zhen [1 ]
Wu, Honglei [1 ]
机构：
[1] Shandong Univ, Hosp 2, Dept Gastroenterol, 247 Beiyuan St, Jinan 250033, Shandong, Peoples R China
来源：
TECHNOLOGY IN CANCER RESEARCH & TREATMENT | 2019年 / 18卷
关键词：
miR-376c-3p; SYF2; gastric cancer; tumor suppressor; cell behaviors; SYF2; PROLIFERATION; METASTASIS; PROGNOSIS; CYCLE;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MicroRNA-376c-3p was previous reported to have a crucial role in the progression of human cancer. This study was aimed to investigate the influence of microRNA-376c-3p on the proliferation and migration of human gastric cancer cells and the associated mechanism. We explored the expression of microRNA-376c-3p in gastric cancer cells using reverse transcription-quantitative polymerase chain reaction. Also, we analyzed the association and biological significance of microRNA-376c-3p and SYF2 pre-mRNA-splicing factor in gastric cancer. MicroRNA-376c-3p expression was found downregulated in gastric cancer cell lines compared to the normal cell line. MicroRNA-376c-3p directly targeted SYF2 and reduced SYF2 expression. Overexpression of microRNA-376c-3p inhibits gastric cancer cell proliferation and migration. Besides that, overexpression of SYF2 abrogates the inhibitory influences on gastric cancer cell behaviors caused by microRNA-376c-3p mimic. These results showed that microRNA-376c-3p inhibits the proliferation and migration of gastric cancer cells via targeting SYF2.
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页数：6
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  • [11] RETRACTED: The MicroRNA-217 Functions as a Potential Tumor Suppressor in Gastric Cancer by Targeting GPC5 (Retracted Article)
    Wang, Hui
    Dong, Xiaolin
    Gu, Xin
    Qin, Rong
    Jia, Hongping
    Gao, Jianpeng
    [J]. PLOS ONE, 2015, 10 (06):
  • [12] MiR-376c-3p regulates the proliferation, invasion, migration, cell cycle and apoptosis of human oral squamous cancer cells by suppressing HOXB7
    Wang, Kai
    Jin, Jun
    Ma, Tengxiao
    Zhai, Hongfeng
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2017, 91 : 517 - 525
  • [13] MicroRNA-376c-3p Facilitates Human Hepatocellular Carcinoma Progression via Repressing AT-Rich Interaction Domain 2
    Wang, Yuan
    Chang, Weiping
    Chang, Wanli
    Chang, Xiaowei
    Zhai, Song
    Pan, Guoying
    Dang, Shuangsuo
    [J]. JOURNAL OF CANCER, 2018, 9 (22): : 4187 - 4196
  • [14] SYF2 is upregulated in human epithelial ovarian cancer and promotes cell proliferation
    Yan, Sujuan
    Deng, Yan
    Qiang, Yong
    Xi, Qinghua
    Liu, Rong
    Yang, Shuyun
    Liu, Jian
    Tang, Chunhui
    Zhong, Jianxin
    Wang, Yingying
    [J]. TUMOR BIOLOGY, 2015, 36 (06) : 4633 - 4642
  • [15] Molecular pathology of gastric cancer: Research and practice
    Yasui, Wataru
    Sentani, Kazuhiro
    Sakamoto, Naoya
    Anami, Katsuhiro
    Naito, Yutaka
    Oue, Naohide
    [J]. PATHOLOGY RESEARCH AND PRACTICE, 2011, 207 (10) : 608 - 612
  • [16] Overexpression of SYF2 correlates with enhanced cell growth and poor prognosis in human hepatocellular carcinoma
    Zhang, Shusen
    Shi, Weidong
    Chen, Yuyan
    Xu, Zhiwei
    Zhu, Jia
    Zhang, Tingting
    Huang, Wei
    Ni, Runzhou
    Lu, Cuihua
    Zhang, Xiubing
    [J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 2015, 410 (1-2) : 1 - 9
  • [17] Upregulation of SYF2 in esophageal squamous cell carcinoma promotes tumor cell proliferation and predicts poor prognosis
    Zhu, Junya
    Ji, Lili
    Zhang, Jianguo
    Yang, Lei
    Guan, Chengqi
    Wang, Yayun
    Zhu, Jia
    Liang, Li
    Ni, Runzhou
    [J]. TUMOR BIOLOGY, 2014, 35 (10) : 10275 - 10285
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