RETRACTED: Influence of miR-376c-3p/SYF2 Axis on the Progression of Gastric Cancer (Retracted Article)

被引：0
作者：
Liu, Bin [1 ]
Li, Guangchun [1 ]
Zhang, Zhen [1 ]
Wu, Honglei [1 ]
机构：
[1] Shandong Univ, Hosp 2, Dept Gastroenterol, 247 Beiyuan St, Jinan 250033, Shandong, Peoples R China
来源：
TECHNOLOGY IN CANCER RESEARCH & TREATMENT | 2019年 / 18卷
关键词：
miR-376c-3p; SYF2; gastric cancer; tumor suppressor; cell behaviors; SYF2; PROLIFERATION; METASTASIS; PROGNOSIS; CYCLE;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MicroRNA-376c-3p was previous reported to have a crucial role in the progression of human cancer. This study was aimed to investigate the influence of microRNA-376c-3p on the proliferation and migration of human gastric cancer cells and the associated mechanism. We explored the expression of microRNA-376c-3p in gastric cancer cells using reverse transcription-quantitative polymerase chain reaction. Also, we analyzed the association and biological significance of microRNA-376c-3p and SYF2 pre-mRNA-splicing factor in gastric cancer. MicroRNA-376c-3p expression was found downregulated in gastric cancer cell lines compared to the normal cell line. MicroRNA-376c-3p directly targeted SYF2 and reduced SYF2 expression. Overexpression of microRNA-376c-3p inhibits gastric cancer cell proliferation and migration. Besides that, overexpression of SYF2 abrogates the inhibitory influences on gastric cancer cell behaviors caused by microRNA-376c-3p mimic. These results showed that microRNA-376c-3p inhibits the proliferation and migration of gastric cancer cells via targeting SYF2.
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页数：6
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