Recent Advances in Synthetic Bioelastomers

被引：100

作者：

Shi, Rui ^{[2
]}

Chen, Dafu ^{[2
]}

Liu, Quanyong ^{[1
]}

Wu, Yan ^{[1
]}

Xu, Xiaochuan ^{[3
]}

Zhang, Liqun ^{[1
]}

Tian, Wei ^{[2
,3
]}

机构：

[1] Beijing Univ Chem Technol, Beijing Key Lab Preparat & Proc Novel Polymer Mat, Beijing 100029, Peoples R China

[2] Beijing Res Inst Traumatol & Orthopaed, Lab Bone Tissue Engn, Beijing 100035, Peoples R China

[3] Peking Univ, Clin Med Coll 4, Beijing JiShuiTan Hosp, Dept Spine Surg, Beijing 100035, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2009年 / 10卷 / 10期

基金：

北京市自然科学基金; 美国国家科学基金会;

关键词：

bioelastomer; biodegradable; biocompatible; polyurethanes; polyphosphazenes; poly(ether ester); poly(epsilon-caprolactone); poly(1,3-trimethylene carbonate); poly(polyol sebacate)s; poly(diol-citrates); poly(ester amide) s; IN-VITRO DEGRADATION; ESTER) THERMOPLASTIC ELASTOMERS; BIODEGRADABLE POLYURETHANE SCAFFOLDS; POROUS POLYESTERURETHANE FOAM; PEO-PBT COPOLYMERS; POLY(ESTER AMIDE)S; POLY(GLYCEROL SEBACATE); POLY(ETHYLENE GLYCOL); DEFORMATION-BEHAVIOR; EPSILON-CAPROLACTONE;

D O I：

10.3390/ijms10104223

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This article reviews the degradability of chemically synthesized bioelastomers, mainly designed for soft tissue repair. These bioelastomers involve biodegradable polyurethanes, polyphosphazenes, linear and crosslinked poly(ether/ester)s, poly(e-caprolactone) copolymers, poly(1,3-trimethylene carbonate) and their copolymers, poly(polyol sebacate) s, poly(diol-citrates) and poly(ester amide) s. The in vitro and in vivo degradation mechanisms and impact factors influencing degradation behaviors are discussed. In addition, the molecular designs, synthesis methods, structure properties, mechanical properties, biocompatibility and potential applications of these bioelastomers were also presented.

引用

页码：4223 / 4256

页数：34

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