Synthesis and anti-human hepatocellular carcinoma activity of new nitric oxide-releasing glycosyl derivatives of oleanolic acid

被引：51

作者：

Huang, Zhangjian ^{[1
]}

Zhang, Yihua ^{[1
]}

Zhao, Li ^{[2
]}

Jing, Yongwang ^{[3
]}

Lai, Yisheng ^{[1
]}

Zhang, Luyong ^{[3
]}

Guo, Qinglong ^{[2
]}

Yuan, Shengtao ^{[3
]}

Zhang, Jianjun ^{[4
]}

Chen, Li ^{[1
]}

Peng, Sixun ^{[1
]}

Tian, Jide ^{[5
]}

机构：

[1] China Pharmaceut Univ, Ctr Drug Discovery, Nanjing 210009, Peoples R China

[2] China Pharmaceut Univ, Jiangsu Key Lab Carcinogenesis & Intervent, Nanjing 210009, Peoples R China

[3] China Pharmaceut Univ, New Drug Screening Ctr, Nanjing 210009, Peoples R China

[4] China Pharmaceut Univ, Dept Pharmaceut, Nanjing 210009, Peoples R China

[5] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 03期

基金：

高等学校博士学科点专项科研基金;

关键词：

HEPG2; CELLS; DOPAMINE; PRODRUGS; DESIGN; DONOR; DRUG;

D O I：

10.1039/b918846k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of nitric oxide (NO)-releasing glycosyl derivatives (2-14) of oleanolic acid were synthesized to improve the aqueous solubility and cytotoxicity of the parent compound 1. Derivative 3 exhibited better solubility and strong cytotoxicity against human hepatocellular carcinoma (HCC) in vitro. Furthermore, 3 displayed low acute toxicity to mice and significantly inhibited the growth of HCC tumors in vivo, indicating that 3 may be a promising candidate for the treatment of human HCC.

引用

页码：632 / 639

页数：8

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