The relationship of maternal glycemia to childhood obesity and metabolic dysfunction?

被引：22

作者：

Landon, Mark B. ^{[1
]}

Mele, Lisa ^{[2
]}

Varner, Michael W. ^{[3
]}

Casey, Brian M. ^{[4
]}

Reddy, Uma M. ^{[5
]}

Wapner, Ronald J. ^{[6
]}

Rouse, Dwight J. ^{[7
]}

Tita, Alan T. N. ^{[8
]}

Thorp, John M. ^{[9
]}

Chien, Edward K. ^{[10
]}

Saade, George ^{[11
]}

Grobman, William ^{[12
]}

Blackwell, Sean C. ^{[13
]}

VanDorsten, J. Peter ^{[14
]}

Johnson, F. ^{[15
]}

Wylie, S. ^{[15
]}

Habash, D. ^{[15
]}

Heintzman, S. ^{[15
]}

Nini, E. ^{[15
]}

Iams, J. ^{[15
]}

Durnwald, C. ^{[15
]}

Hill, K. ^{[16
]}

Thompson, M. ^{[16
]}

Sowles, A. ^{[16
]}

Anderson, G. ^{[16
]}

Moseley, L. ^{[17
]}

Price, J. ^{[17
,29
]}

Sias, A. ^{[17
]}

Gonzales, K. ^{[17
]}

Delira, Y. ^{[17
]}

Talucci, M. ^{[18
]}

Carmona, V. ^{[18
]}

Quezada, I. ^{[18
]}

Ranzini, A. ^{[18
]}

Lake, M. ^{[19
]}

Davis, S. ^{[19
]}

Hoffman, M. ^{[20
]}

Lynch, S. ^{[20
]}

Benson, J. ^{[20
]}

Kitto, C. ^{[20
]}

Plante, L. ^{[21
]}

Kitto, C. ^{[20
]}

Plante, L. ^{[21
]}

Tocci, C. ^{[21
]}

Williams, Y. ^{[21
]}

Allard, D. ^{[22
]}

Anderson, B. ^{[22
]}

Pereda, K. ^{[22
]}

Hipolito, E. ^{[22
]}

McNamara, J. ^{[22
]}

机构：

[1] Ohio State Univ, Coll Med, Dept Obstet & Gynecol, 395 West 12th Ave,Room 572, Columbus, OH 43210 USA

[2] George Washington Univ, Biostat Ctr, Washington, DC USA

[3] Univ Utah, Hlth Sci Ctr, Salt Lake City, UT USA

[4] Univ Texas Southwestern Med Ctr Dallas, Dept Obstet & Gynecol, Dallas, TX USA

[5] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Dept Obstet & Gynecol, Bethesda, MD USA

[6] Columbia Univ, Dept Obstet & Gynecol, New York, NY USA

[7] Brown Univ, Dept Obstet & Gynecol, Providence, RI USA

[8] Univ Alabama Birmingham, Dept Obstet & Gynecol, Birmingham, AL 35294 USA

[9] Univ N Carolina, Dept Obstet & Gynecol, Chapel Hill, NC 27515 USA

[10] Case Western Reserve Univ, Dept Obstet & Gynecol, MetroHlth Med Ctr, Cleveland, OH 44106 USA

[11] Univ Texas Med Branch, Galveston, TX 77555 USA

[12] Northwestern Univ, Dept Obstet & Gynecol, Chicago, IL 60611 USA

[13] Univ Texas Hlth Sci Ctr Houston, Childrens Mem Hermann Hosp, Houston, TX 77030 USA

[14] Med Univ South Carolina, Dept Obstet & Gynecol, Charleston, SC 29425 USA

[15] Ohio State Univ, Columbus, OH 43210 USA

[16] Univ Utah, Hlth Sci Ctr, Salt Lake City, UT USA

[17] Univ Texas Southwestern Med Ctr Dallas, Dallas, TX 75390 USA

[18] Columbia Univ, New York, NY USA

[19] St Peters Univ Hosp, New Brunswick, NJ USA

[20] Christiana Care, Newark, DE USA

[21] Drexel Univ, Philadelphia, PA 19104 USA

[22] Brown Univ, Providence, RI 02912 USA

[23] Univ Alabama Birmingham, Birmingham, AL USA

[24] Univ N Carolina, Chapel Hill, NC 27515 USA

[25] Case Western Reserve Univ, MetroHlth Med Ctr, Cleveland, OH 44106 USA

[26] Univ Texas Med Branch, Galveston, TX 77555 USA

[27] Northwestern Univ, Evanston Hosp, NorthShore Hlth Syst, Chicago, IL 60611 USA

[28] Univ Texas Hlth Sci Ctr Houston, Childrens Mem Hermann Hosp, Houston, TX 77030 USA

[29] George Washington Univ, Biostat Ctr, Washington, DC USA

[30] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD USA

来源：

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE | 2020年 / 33卷 / 01期

关键词：

Childhood obesity; fetal programing; maternal diabetes; GESTATIONAL DIABETES-MELLITUS; WEIGHT-GAIN; GLUCOSE-TOLERANCE; PREGNANCY; RISK; ADIPOSITY; HYPERGLYCEMIA; ASSOCIATION; OVERWEIGHT; EXPOSURE;

D O I：

10.1080/14767058.2018.1484094

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To determine the association of maternal glycemia with childhood obesity and metabolic dysfunction. Study design: Secondary analysis of follow-up data 5?10?years after a mild gestational diabetes mellitus (GDM) treatment trial. The relationship between maternal oral glucose tolerance testing (OGTT) at 24?31-week gestation and body mass index (BMI), fasting glucose, insulin, and anthropometric measurements (sum of skinfolds, subscapular/triceps ratio, and waist circumference) in the offspring of untreated mild GDM and non-GDM (abnormal 50-g screen/normal OGTT) women was assessed. Multivariable regression modeling controlling for maternal and neonatal characteristics was employed. Results: A cohort of 236 untreated mild GDM and 480 non-GDM offspring were analyzed. In the combined cohort, significant correlations existed between fasting, 1, 2, and 3?h maternal glucose and subscapular/triceps ratio (all p?<?.04) and in all OGTT values other than the 2-hour value for homeostatic model assessment-estimated insulin resistance (HOMA-IR) (all p?<?.04) and sum of skinfold measurements (all p?<?.03). No correlation was found between OGTT values and childhood BMI Z-score. Multivariable regression modeling showed that OGTT values were associated with only sum of skinfolds and subscapular/triceps ratio and not with childhood BMI Z-score. Hispanic ethnicity and prepregnancy maternal BMI were most consistently related to childhood BMI Z-score and HOMA-IR, and Hispanic ethnicity with fasting glucose. Conclusions: Among women with untreated mild GDM and those without GDM, maternal glycemia is associated with childhood anthropometric measures of obesity but not childhood BMI, fasting glucose, or insulin resistance. Hispanic ethnicity, maternal BMI, and gestational weight gain were consistently related to childhood BMI.

引用

页码：33 / 41

页数：9

共 40 条

[1] 1994-1996 U.S. singleton birth weight percentiles for gestational age by race, Hispanic origin, and gender. [J].

Alexander G.R. ;

Kogan M.D. ;

Himes J.H. .

Maternal and Child Health Journal, 1999, 3 (4) :225-231

[2]

American College of Obstetricians and Gynecologists, 2013, Obstet Gynecol, V121, P210, DOI http://10.1097/01.AOG.0000425668.87506.4c

[3]

[Anonymous], 2000, CDC growth charts, United States

[4] Interpregnancy Weight Change and Risk for Adverse Perinatal Outcome [J].

Bogaerts, Annick ;

Van den Bergh, Bea R. H. ;

Ameye, Lieveke ;

Witters, Ingrid ;

Martens, Evelyne ;

Timmerman, Dirk ;

Devlieger, Roland .

OBSTETRICS AND GYNECOLOGY, 2013, 122 (05) :999-1009

[5] CRITERIA FOR SCREENING-TESTS FOR GESTATIONAL DIABETES [J].

CARPENTER, MW ;

COUSTAN, DR .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1982, 144 (07) :768-773

[6] Perinatal risk factors for childhood obesity and metabolic dysregulation [J].

Catalano, Patrick M. ;

Farrell, Kristen ;

Thomas, Alicia ;

Huston-Presley, Larraine ;

Mencin, Patricia ;

de Mouzon, Sylvie Hauguel ;

Amini, Saeid B. .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2009, 90 (05) :1303-1313

[7]

Centers for Disease Control and Prevention, tional Health and Nutrition Examination Survey Data, Hy

[8] Gestational Weight Gain and Gestational Diabetes Mellitus Perinatal Outcomes [J].

Cheng, Yvonne W. ;

Chung, Judith H. ;

Kurbisch-Block, Ingrid ;

Inturrisi, Maribeth ;

Shafer, Sherri ;

Caughey, Aaron B. .

OBSTETRICS AND GYNECOLOGY, 2008, 112 (05) :1015-1022

[9] Maternal obesity and risk of gestational diabetes mellitus [J].

Chu, Susan Y. ;

Callaghan, William M. ;

Kim, Shin Y. ;

Schmid, Christopher H. ;

Lau, Joseph ;

England, Lucinda J. ;

Dietz, Patricia M. .

DIABETES CARE, 2007, 30 (08) :2070-2076

[10] Effect of treatment of gestational diabetes mellitus on pregnancy outcomes [J].

Crowther, CA ;

Hiller, JE ;

Moss, JR ;

McPhee, AJ ;

Jeffries, WS ;

Robinson, JS .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (24) :2477-2486

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