IMAGING DIAGNOSIS-NEURONAL CEROID LIPOFUSCINOSIS WITH A CHRONIC SUBDURAL HEMATOMA

被引：15

作者：

Asakawa, Midori Goto ^{[1
]}

Mackillop, Edward ^{[4
]}

Olby, Natasha J. ^{[2
]}

Robertson, Ian D. ^{[3
]}

Cullen, John M. ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Populat Hlth & Pathobiol, Raleigh, NC 27695 USA

[2] N Carolina State Univ, Dept Clin Sci, Raleigh, NC 27695 USA

[3] N Carolina State Univ, Dept Mol Biomed Sci, Coll Vet Med, Raleigh, NC 27695 USA

[4] Pittsburgh Vet Special & Emergency Ctr, Pittsburgh, PA USA

来源：

VETERINARY RADIOLOGY & ULTRASOUND | 2010年 / 51卷 / 02期

关键词：

Dachshund; neuronal ceroid lipofuscinosis; subdural hematoma; BORDER COLLIE; CANINE TPP1; DOGS; MUTATION; GENE; HYDROCEPHALUS;

D O I：

10.1111/j.1140-8261.2009.01642.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

A subdural hematoma was found to accompany neuronal ceroid lipofuscinosis in an 11-month-old Dachshund. Results from clinical, magnetic resonance (MR) imaging, histopathologic, ultrastructural, and molecular assessments are described. The dog had a 3-month history of progressive neurologic signs. In MR images, there was severe asymmetric cerebral atrophy with a subdural hematoma. Histopathologically, there was autofluorescent, periodic acid-Schiff-positive lipopigment in neurons and transmission electron microscopy confirmed a typical curvilinear profile of the storage bodies. We hypothesize that rapid brain atrophy contributed to the subdural hematoma formation, a complication not described previously in dogs with neuronal lipofuscinosis.

引用

页码：155 / 158

页数：4

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