IMAGING DIAGNOSIS-NEURONAL CEROID LIPOFUSCINOSIS WITH A CHRONIC SUBDURAL HEMATOMA

被引：15
作者：
Asakawa, Midori Goto [1 ]
Mackillop, Edward [4 ]
Olby, Natasha J. [2 ]
Robertson, Ian D. [3 ]
Cullen, John M. [1 ]
机构：
[1] N Carolina State Univ, Dept Populat Hlth & Pathobiol, Raleigh, NC 27695 USA
[2] N Carolina State Univ, Dept Clin Sci, Raleigh, NC 27695 USA
[3] N Carolina State Univ, Dept Mol Biomed Sci, Coll Vet Med, Raleigh, NC 27695 USA
[4] Pittsburgh Vet Special & Emergency Ctr, Pittsburgh, PA USA
来源：
VETERINARY RADIOLOGY & ULTRASOUND | 2010年 / 51卷 / 02期
关键词：
Dachshund; neuronal ceroid lipofuscinosis; subdural hematoma; BORDER COLLIE; CANINE TPP1; DOGS; MUTATION; GENE; HYDROCEPHALUS;
D O I：
10.1111/j.1140-8261.2009.01642.x
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
A subdural hematoma was found to accompany neuronal ceroid lipofuscinosis in an 11-month-old Dachshund. Results from clinical, magnetic resonance (MR) imaging, histopathologic, ultrastructural, and molecular assessments are described. The dog had a 3-month history of progressive neurologic signs. In MR images, there was severe asymmetric cerebral atrophy with a subdural hematoma. Histopathologically, there was autofluorescent, periodic acid-Schiff-positive lipopigment in neurons and transmission electron microscopy confirmed a typical curvilinear profile of the storage bodies. We hypothesize that rapid brain atrophy contributed to the subdural hematoma formation, a complication not described previously in dogs with neuronal lipofuscinosis.
引用
收藏
页码：155 / 158
页数：4
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