Documentation of Impaired Coronary Blood Flow in Chronic Obstructive Pulmonary Disease Patients

被引：14
作者：
Selcuk, Hatice [1 ]
Maden, Orhan [1 ]
Selcuk, Mehmet Timur [1 ]
Celenk, Mehmet Kutlu [1 ]
Geyik, Bilal [1 ]
Tufekcioglu, Omac [1 ]
机构：
[1] Turkiye Yuksek Ihtisas Educ & Res Hosp, Dept Cardiol, Ankara, Turkey
来源：
CIRCULATION JOURNAL | 2010年 / 74卷 / 02期
关键词：
Chronic obstructive pulmonary disease; Inflammation; Slow coronary flow; C-REACTIVE PROTEIN; SLEEP-APNEA; ANGINA-PECTORIS; SLOW-FLOW; CARDIOVASCULAR-DISEASE; SYSTEMIC INFLAMMATION; PLASMA-CONCENTRATIONS; LUNG HEALTH; MORTALITY; ARTERIES;
D O I：
10.1253/circj.CJ-09-0557
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: In the current study, the effects of moderate to severe chronic obstructive pulmonary disease (COPD) on coronary blood flow in patients with angiographically proven normal coronary arteries was evaluated. Methods and Results: A total of 85 patients with moderate to severe COPD and 39 age- and sex-matched control partcipants, who underwent diagnostic coronary angiography and found to have normal epicardial coronary angiogram constituted the COPD and control groups, respectively. The 2 groups were compared for Thrombolysis In Myocardial Infarction (TIMI) frame counts in each major coronary artery. The TIMI frame count of the COPD group was significantly higher than that of control group for all 3 major individual coronary arteries: left anterior descending (corrected), 37 +/- 13 vs 20 +/- 4; right coronary artery, 32 +/- 14 vs 21 +/- 4; and left circumflex artery, 34 12 vs 20 5, (P<0.001 for all). In addition, TIMI frame counts in individual coronary arteries were found to be positively correlated with forced expiratory volume 1 s percent, serum high sensitive C-reactive protein and fibrinogen concentrations, in the COPD group. Conclusions: Our findings suggest that an increased slow coronary flow might be a manifestation of harmful effects of COPD on the coronary circulation, regardless of the underlying mechanism. (Circ J 2010; 74: 346-352)
引用
收藏
页码：346 / 352
页数：7
相关论文
共 40 条
[1]   Hospitalizations and mortality in the Lung Health Study [J].
Anthonisen, NR ;
Connett, JE ;
Enright, PL ;
Manfreda, J .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2002, 166 (03) :333-339
[2]   EFFECTS OF SMOKING INTERVENTION AND THE USE OF AN INHALED ANTICHOLINERGIC BRONCHODILATOR ON THE RATE OF DECLINE OF FEV(1) - THE LUNG HEALTH STUDY [J].
ANTHONISEN, NR ;
CONNETT, JE ;
KILEY, JP ;
ALTOSE, MD ;
BAILEY, WC ;
BUIST, AS ;
CONWAY, WA ;
ENRIGHT, PL ;
KANNER, RE ;
OHARA, P ;
OWENS, GR ;
SCANLON, PD ;
TASHKIN, DP ;
WISE, RA .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 272 (19) :1497-1505
[3]   The effects of a smoking cessation intervention on 14.5-year mortality - A randomized clinical trial [J].
Anthonisen, NR ;
Skeans, MA ;
Wise, RA ;
Manfreda, J ;
Kanner, RE ;
Connett, JE .
ANNALS OF INTERNAL MEDICINE, 2005, 142 (04) :233-239
[4]   EFFECTS OF PULMONARY-FUNCTION ON MORTALITY [J].
BEATY, TH ;
NEWILL, CA ;
COHEN, BH ;
TOCKMAN, MS ;
BRYANT, SH ;
SPURGEON, HA .
JOURNAL OF CHRONIC DISEASES, 1985, 38 (08) :703-710
[5]  
Centers for Disease Control and Prevention, 2007, AM J RESP CRIT CARE, V55
[6]  
Cesar LAM, 1996, BRAZ J MED BIOL RES, V29, P605
[7]   Lipids and pulmonary function in the Third National Health and Nutrition Examination Survey [J].
Cirillo, DJ ;
Agrawal, Y ;
Cassano, PA .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2002, 155 (09) :842-848
[8]   Coronary slow-flow causing transient myocardial hypoperfusion in patients with cardiac syndrome X: Long-term clinical and functional prognosis [J].
Fragasso, Gabriele ;
Chierchia, Sergio L. ;
Arioli, Francesco ;
Carandente, Orazio ;
Gerosa, Stefano ;
Carlino, Mauro ;
Palloshi, Altin ;
Gianolli, Luigi ;
Calori, Giliola ;
Fazio, Ferruccio ;
Margonato, Alberto .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2009, 137 (02) :137-144
[9]   Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis [J].
Gan, WQ ;
Man, SFP ;
Senthilselvan, A ;
Sin, DD .
THORAX, 2004, 59 (07) :574-580
[10]   Markers of inflammation and oxidative stress in exacerbated chronic obstructive pulmonary disease patients [J].
Gerritsen, WBM ;
Asin, J ;
Zanen, P ;
van den Bosch, JMM ;
Haas, FJLM .
RESPIRATORY MEDICINE, 2005, 99 (01) :84-90
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