RETRACTED: Artemisia Extracts and Artemisinin-Based Antimalarials for COVID-19 Management: Could These Be Effective Antivirals for COVID-19 Treatment? (Retracted Article)

被引:16
作者
Agrawal, Pawan K. [1 ]
Agrawal, Chandan [1 ]
Blunden, Gerald [2 ]
机构
[1] Nat Prod Inc, 7963 Anderson Pk Lane, Westerville, OH 43081 USA
[2] Univ Portsmouth, Sch Pharm & Biomed Sci, Portsmouth PO1 2DT, Hants, England
关键词
Artemisia; artemisinins; antiviral; drug repurposing; COVID-19; COV 3CL PROTEASE; ANNUA-L; PULMONARY-FIBROSIS; NATURAL COMPOUNDS; ARTEANNUIN-B; ARTESUNATE; DRUG; MALARIA; SARS-COV-2; INHIBITION;
D O I
10.3390/molecules27123828
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
As the world desperately searches forways to treat the coronavirus disease 2019 (COVID-19) pandemic, a growing number of people are turning to herbal remedies. The Artemisia species, such as A. annua and A. afra, in particular, exhibit positive effects against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and COVID-19 related symptoms. A. annua is a source of artemisinin, which is active against malaria, and also exhibits potential for other diseases. This has increased interest in artemisinin's potential for drug repurposing. Artemisinin-based combination therapies, so-called ACTs, have already been recognized as first-line treatments against malaria. Artemisia extract, as well as ACTs, have demonstrated inhibition of SARS-CoV-2. Artemisinin and its derivatives have also shown anti-inflammatory effects, including inhibition of interleukin-6 (IL-6) that plays a key role in the development of severe COVID-19. There is now sufficient evidence in the literature to suggest the effectiveness of Artemisia, its constituents and/or artemisinin derivatives, to fight against the SARS-CoV-2 infection by inhibiting its invasion, and replication, as well as reducing oxidative stress and inflammation, and mitigating lung damage.
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页数:21
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