Biodistribution and Radiation Dosimetry in Humans of a New PET Ligand, 18F-PBR06, to Image Translocator Protein (18 kDa)

被引：41

作者：

Fujimura, Yota ^{[1
]}

Kimura, Yasuyuki ^{[1
]}

Simeon, Fabrice G. ^{[1
]}

Dickstein, Leah P. ^{[1
]}

Pike, Victor W. ^{[1
]}

Innis, Robert B. ^{[1
]}

Fujita, Masahiro ^{[1
]}

机构：

[1] NIMH, Mol Imaging Branch, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF NUCLEAR MEDICINE | 2010年 / 51卷 / 01期

关键词：

MIRD scheme; defluorination; inflammation; microglia; aryloxyanilide; PERIPHERAL BENZODIAZEPINE-RECEPTOR; NONHUMAN-PRIMATES; RADIOLIGAND; BRAIN;

D O I：

10.2967/jnumed.109.068064

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

As a PET biomarker for inflammation, translocator protein (18 kDa) (TSPO) can be measured with an F-18-labeled aryloxyanilide, F-18-N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline (F-18-PBR06), in the human brain. The objective of this study was to estimate the radiation absorbed doses of F-18-PBR06 based on biodistribution data in humans. Methods: After the injection of F-18-PBR06, images were acquired from head to thigh in 7 healthy humans. Urine was collected at various time points. Radiation absorbed doses were estimated by the MIRD scheme. Results: Moderate to high levels of radioactivity were observed in organs with high densities of TSPO and in organs of metabolism and excretion. Bone had low levels of radioactivity. The effective dose was 18.5 mu Sv/MBq. Conclusion: The effective dose of F-18-PBR06, compared with other F-18 radioligands, was moderate. This radioligand had negligible defluorination, as indirectly assessed by bone radioactivity. Doses to the gallbladder wall and spleen may limit the amount of permissible injected radioactivity.

引用

页码：145 / 149

页数：5

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